Human occupation of the area around Long Preston goes back to prehistoric times as remains have been found at Victoria Cave on the hills above Settle. A Stone Age axe head was also found in the area of Bookil Gill.
Middle Ages
In 1086, Long Preston was known as Prestune, meaning "the priest's farmstead or town". Later "Long" was added, referring to its linear development and distinguishing it from the many other Prestons. A school was built in the village during the reign of Edward IV as part of the Hammerton Chapel. It is likely that it was closed in 1541 during the dissolution of the religious houses. In 1672 the Petty School was held, most likely either in the chapel or in a building near an old vicarage. A new school replaced the Petty School in 1819.
Industrial age
In the 18th and 19th centuries, Long Preston was dominated by agriculture and the trades associated with it. In the 1750s a turnpike road was constructed from Long Preston to Settle. In the 1960s this road was raised, widened, and straighted. Several homes and farms were demolished to accomplish this. In 1790, a cotton spinning mill was constructed, possibly on the site of an old corn mill. The mill was demolished in 1881 due to flooding. Later on Fleets cotton mill was built, which was three storeys high and water powered. The railway was opened in 1849 and expanded in 1875 with the building of the Settle-Carlisle Line. It declined in the 1970s and '80s but is now seeing an increase in heavy freight and passenger traffic. In 1801 the population of Long Preston was 573; this rose to 808 in 1831 but dropped to 610 in 1961.
Modern day
Between 1923 and 1935, Long Preston was the railhead for the construction of Stocks Reservoir built by the Fylde Water Board. Steam traction engines hauled material between the FWB depot, to the west of the current station, by road to Tosside where connection was made with a 3-foot gauge industrial railway system that served the dam construction project. In the 20th century, most people were employed in the village at the garage, wool warehouse, auction mart, farms or in the surrounding area, e.g. Skipton. A number of houses were rented at Long Preston making it affordable to live there. In the 1960s people started to purchase their own homes. In the late 1950s and early 1960s, there was a livestock auction mart, shoe shop, tailors, butchers, bakers, post office, cafés, wool warehouse and corn mill. A bypass was proposed and was given the go-ahead in 1994 but after the 1997 general election, with Labour gaining power, the bypass was scrapped. Long Preston is the home of audiobook producer Magna Story Sound. Long Preston is served by Long Preston railway station, which is on the Leeds to Morecambe Line. Long Preston has a primary school, Long Preston Endowed School, with around 60 pupils attending over a range of seven year groups.