In The Forgotten Revolution: How Science Was Born in 300 BC and Why It Had to Be Reborn, Russo promotes the belief that Hellenistic science in the period 320–144 BC reached heights not achieved by Classical age science, and proposes that it went further than ordinarily thought, in multiple fields not normally associated with ancient science. According to Russo, Hellenistic scientists were not simply forerunners, but actually achieved scientific results of high importance, in the fields of "mathematics, solid and fluid mechanics, optics, astronomy, anatomy, physiology, scientific medicine," even psychoanalysis. They may have even discovered the inverse square law of gravitation. Hellenistic scientists, among whom Euclid, Archimedes, Eratosthenes, developed an axiomatic and deductive way of argumentation. When this way of argumentation was dropped, the ability to understand the results were lost as well. Thus Russo conjectures that the definitions of elementary geometric objects were introduced in Euclid's Elements by Heron of Alexandria, 400 years after the work was completed. More concretely, Russo shows how the theory of tides must have been well-developed in Antiquity, because several pre-Newtonian sources relay various complementary parts of the theory without grasping their import or justification. Hellenistic science was focused on the city of Alexandria. The emerging scientific revolution in Alexandria was ended when Ptolemy VIII Physcon came to power. He engaged in mass purges and expulsions of all intellectuals. Other centers of Hellenistic science mentioned in Russo's book were Antioch, Pergamon, Cyzicus, Rhodes, Syracuse and Massilia. He also concludes that the 17th-century scientific revolution in Europe was due in large part to the recovery of Hellenistic science. The Forgotten Revolution has received mixed reviews, praising Russo's enthusiasm but noting that his conclusions outreach his sources.
''L'America dimenticata''
In L'America dimenticata, Russo suggests that the Americas were known to some European civilizations in ancient times, probably discovered by the Phoenicians or the Carthaginians, but that the knowledge was lost under Roman expansion in the second century BC. Russo notes paintings dating to the Roman period and representing American fruits, and small Mesoamerican toys representing wheeled trucks, when the wheel had not been invented nor used in pre-Columbian times. With the collapse of the Hellenistic world under the attacks of the Romans around the middle of the 2nd century BC, these geographic notions were lost. Later Ptolemy incorrectly identified the Blessed Islands with the Canaries and since it was known that the Blessed Islands were at the antipodes relative to the eastern part of China, Ptolemy made ends meet by erroneously enlarging the longitude of all known places, and shrinking the width of a degree of longitude. With this correction Lucio Russo manages to pinpoint the position of the mythical Thule, reached in the 4th century BC by explorer Pytheas, on the coast of Greenland. In addition he sheds a new light on an obscure sentence of Pliny according to which Hipparchus would have enlarged the ecumene by 26,000 stadia.