The M11 begins in the suburb of Bassonia at a junction with the M95 Bellairs Road. It goes north through the suburb of Bassonia as Comaro Street to reach a junction with the N12 Highway. Just after the N12, it enters the suburb of Oakdene as Oak Avenue and proceeds northwards to enter the suburb of Rosettenville as Prairie Street. After meeting the M34, it is named Diagonal Street and proceeds northwards. After bypassing the Regents Park Estate, it becomes Wemmer Pan Road and makes a loop around the Wemmer Pan to meet the western end of the N17 Highway just east of the Springfield Suburb. From the N17 junction, the M11 continues northwards to meet the M2 Highway as Mooi Street and enter the City and Suburban Area of Johannesburg. As Mooi Street becomes a one-way street at its junction with the R29 Road, the M11 joins the R29 westwards up to the junction with Von Wielligh Street in the suburb of Marshalltown, where the M11 resumes going northwards. Soon after, the M11 meets the two roads that form the R24 Road. By Lillian Ngoyi Street near the MTN North Taxi Rank, the M11 becomes Klein Street and continues northwards to pass through Joubert Park, where the Johannesburg Art Gallery is located. At the junction with Smit Street , the M11 joins the M10 eastwards up to the next junction, where it enters the suburb of Hillbrow, returns to facing northwards and resumes being called Klein Street. By Hillbrow Police Station, it becomes Clarendon Place, meeting the eastern end of Empire Road, before becoming Willie Street. At the Houghton Drive off-ramp, the M11 becomes Louis Botha Avenue. The M11 proceeds as Louis Botha Avenue at the top of the Johannesburg CBD in the suburbs of Hillbrow and Berea and then heads north-east passing through Houghton to the north and Yeoville and Bellevue to the south. In Houghton, it passes close to the private boy's schools of St John's College and King Edward VII school. After this point, the road curves and is ominously nicknamed Deathbend due to the number of car accidents at the spot. Here the M161st Avenue in Houghton intersects this route from the left at a t-junction and is briefly co-signed. The route then enters the suburb of Orange Grove passing the new Victory Theatre. Midway through Orange Grove, the road bends northwards and the M16 splits off to the right as 8th Street. The M11 passes through Orchards and is intersected by R25 and then passes Sydenham and smaller suburbs of Maryvale, Forbesdale, Cheltondale, Rouxville and Hawkins Estate. The road then crosses the M40 at Atholl Road in the suburbs of Highlands North and Waverly. The road later crosses the M30 Corlett Drive inBramley before reaching, a short distance later, the M54 Artwright Avenue in the light industrial suburb of Wynberg with the old township of Alexandra close by. The road still designated the M11 continues now as the Pretoria Main Road reaching M60 Marlboro Drive intersection where the M1De Villiers Graaff motorway can be accessed. Crossing the intersection the M11 continues north parallel to the M1 on the left as the Eastern Service Road before reaching its end at the intersection of the R55 Woodmead Drive at Woodlands. The road continues northwards as the R101 Old Pretoria Road.
