MAM domain


MAM domain is an evolutionary conserved protein domain. It is an extracellular domain found in many receptors.
A 170 amino acid domain, the so-called MAM domain, has been recognised in the extracellular region of functionally diverse proteins. These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin ; A5 antigen ; and receptor-like tyrosine protein phosphatase. The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.

Human proteins containing this domain

; EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2; MEP1A; MEP1B;
NPNT; NRP1; NRP2; PRSS7; PTPRK; PTPRM; PTPRO; PTPRT;
PTPRU; ZAN