MAP2K4
Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.
MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2 and MAPK3/ERK1 are not phosphorylated by MAP2K4. MAP2K4 is phosphorylated and activated by MAP3K1/MEKK1. Knockout mouse studies suggest roles for MAP2K4 in mediating T cell development and liver organogenesis.Interactions
MAP2K4 has been shown to interact with:
