MCM7


DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MCM7 has been shown to interact with: