MIR34A
MicroRNA 34a is a MicroRNA that in humans is encoded by the MIR34A gene.Function
microRNAs are short non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA, which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star products. The mature miRNA is incorporated into a RNA-induced silencing complex, which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.miR-34a suppresses the gene expression of the NAMPT gene which encodes the nicotinamide phosphoribosyltransferase enzyme which is the rate-limiting enzyme in the nicotinamide adenine dinucleotide salvage pathway, resulting in reduced NAD. miR-34a suppression of gene expression also reduces levels of sirtuin 1. Aging and obesity increases levels of miR-34a.
