The MacDonnells of Antrim are descended from John Mor MacDonald, chief of the Clan MacDonald of Dunnyveg. John Mor MacDonald was the second son of GoodJohn of Islay, Lord of the Isles, 6th chief of Clan Donald, through John of Islays second marriage to Princess Margaret Stewart, daughter of King Robert II of Scotland. John Mor MacDonald married Margery Byset, daughter of the Mac Eoin Bissett, Lord of the Glens of Antrim. Although the MacDonnells would a century and a half later claim that her dowry included the lordship itself, this is false because the Mac Eoin Bissetts remained in possession of it into the early or mid 16th century. However following the death in battle, in support of his friends and kinsmen the O'Neills against the O'Donnells, of the last known Mac Eoin Bissett in 1522, the recently arrived MacDonnells appear to have started making their own gains in the region and eventually used the earlier marriage to claim they had rights to the Bissett lordship. The MacDonnells already possessed Dunnyvaig Castle on the Isle of Islay and lands in Kintyre, Scotland. The MacDonnells of Antrim did not become a separate branch of Clan Donald until 1558, when they were part of Clan MacDonald of Dunnyveg, when Somhairle Buidhe MacDonnell obtained the lordship of the territory in Ireland from James MacDonald, 6th of Dunnyveg.
15th century
John Mor was assassinated by James Campbell in 1427. John's son Donald Balloch MacDonald, the second chief, led the clan when they fought and won at the first Battle of Inverlochy. This was in support of their cousin Alexander of Islay, Earl of Ross, 3rd Lord of the Isles and 8th chief of Clan Donald. The MacDonalds were supported by the Clan Cameron. They fought against the Royal forces of the Earl of Mar who was supported by the Clan MacKintosh. The third Chief, Sir John Mor, with his heir John Cathanach and three grandsons, were apprehended through the treachery of the Macdonald of Ardnamurchan and were executed in Edinburgh for treason. One of his sons, Alexander, fled to Ireland. MacIian of Ardnamurchan, who had also betrayed Alexander MacDonald of Lochalsh, was himself killed in 1518 by those who he had betrayed.
16th century
On the death of James MacDonald, the sixth chief of the Clan MacDonald of Dunnyveg and Antrim, the Antrim Glens were seized by one of his younger brothers, Sorley Boy MacDonnell. Somhairle is best known for establishing the MacDonnell clan in Antrim and resisting the campaign of Shane O'Neill and the English crown to expel the clan from Ireland. In 1565 under Sorley Boy MacDonnell the Clan MacDonnell of Antrim and Dunnyveg fought the Battle of Glentasie against Shane O'Neill. Alaster, the eldest son of Sorley Boy was killed in 1585, his head was placed on a spike at Baile-atha-cliath.
17th century
Castles
Dunluce Castle was the seat of MacDonald Earl of Antrim, in Ireland.
Dunanynie Castle
Kinbane Castle
Red Bay Castle
Dunnyvaig Castle in was the Earl of Antrims seat in Scotland where he headed the Clan MacDonald of Dunnyveg