Titheradge was born in Melbourne, to a theatrical English family. She was the daughter of the actor George Titheradge and his wife Alma, née Saegert ; her younger brotherDion became an actor and playwright. She was educated at a private school in Hampstead, and in 1902, shortly after her fifteenth birthday, she appeared at the Garrick Theatre, London, as the Second Water Baby in Rutland Barrington's adaptation of The Water Babies. Barrington recalled in his memoirs "Madge Titheradge was our première danseuse and made a great success with her dance outside the little school-house, or rather cottage; she danced with such evident enjoyment of her work." Over the next three years Titheradge performed at a succession of West End theatres, including the Haymarket and His Majesty's, appearing at the latter as Mimi in Herbert Beerbohm Tree's production of Trilby. In 1907 she appeared at the Playhouse with Cyril Maude in a French farce adapted into English as "French as He is Spoke", and the following year played the same role in French at His Majesty's in the original version, L'Anglais tel qu'on le parle, with Coquelin aîné.
1908–1928
In 1908 Titheradge joined Lewis Waller's company, in which she played her first Shakespearian role, Princess Katherine in Henry V. In 1910 she married the actor Charles Quartermaine, with whom she appeared on stage in several productions. The marriage was happy at first, but the couple grew apart and in 1919 they divorced. Titheradge rejoined Waller for several later productions in London, New York and on tour in the US and Australia – her only return to the country in which she was born. In London in December 1914 she played the name part in J. M. Barrie's Peter Pan, with Hilda Trevelyan as Wendy and the fifteen-year-old Noël Coward as Slightly. She made her screen debut in the 1915 film Brigadier Gerard starring opposite Waller. Her obituarist in The Times wrote of the next phase of her career: Titheradge's roles in the 1920s included Desdemona to Tearle's Othello, Nora Helmer in Ibsen's A Doll's House and Beatrice in Much Ado About Nothing with Tearle as Benedick. She created two roles in plays by Coward: Nadya in The Queen Was in the Parlour, and Janet Ebony in Home Chat. She then went to New York, and at the Majestic Theatre in January 1928, she played Anna, Baroness Ostermann in Ashley Dukes's "The Patriot".
In 1928 Titheradge married an American businessman, Edgar Park, and temporarily retired. Sir John Gielgud, who greatly admired Titheradge, recalled that her husband lost his fortune in the Wall Street Crash of 1929, leading her to return to the stage. After nearly five years absence she reappeared in the West End at the Haymarket in December 1932 as Clary Frohner in Business with America. At the Globein September 1933 she succeeded Fay Compton as Norma Matthews in " Proscenium", co-starring with Ivor Novello. One of her most celebrated roles came late in her career, when she played Julie Cavendish in "Theatre Royal" by Edna Ferber and George S. Kaufman directed by Coward at the Lyric Theatre in October 1934. She co-starred with Marie Tempest and the young Laurence Olivier in a thinly-disguised parody of the American theatrical family the Barrymores. At Wyndham's Theatre in, September 1936, again directed by Coward, she played the title role in Jacques Deval's comedy Mademoiselle, heading a cast that included Isabel Jeans, Greer Garson and Cecil Parker. During the run of the play her health began to decline; she suffered from severe arthritis, and after one more role – Edith Venables in "A Thing Apart", in March 1938 – she retired. Her husband died in that year. Titheradge died on 14 November 1961, at the age of 74, at her house in Fetcham, Surrey.