Scott turned professional in 2000 and has only two defeats to his name. His wins include former amateur star Terry McGroom and journeymen David Bostice and Louis Monaco, he took a big step up in early 2007 and defeated former contender Charles Shufford. He did not fight between December 2008 and the beginning of 2012, due to a bicep injury. He has since recovered from the injury and made a comeback in early 2012. Scott was under the tuition of boxing Hall of Fame trainer Jesse Reid until 2014 when the pair split because Scott believed Father Time was catching up with Reid, Scott then reunited with his former amateur coach, Fred Jenkins. Scott is promoted by Goossen-Tutor. Scott was scheduled to fight on the Paul Williams vs. Nobuhiro Ishida undercard at the American Bank Center, Corpus Christi, Texas. The fight took place on February 18, 2012. The opponent was heavyweight journeymanKendrick Releford. It marked Scott's first return to the boxing ring, more than three years after his last fight. It was the second time Scott faced Releford in his career, as they fought back in January 2006. As the case for their first fight, Scott won by unanimous decision. Scott's second fight in 2012 was on June 23, 2012 at Sportsmen's Lodge, Studio City, California. He faced off against the Mexicanheavyweight boxer, Alvaro Morales. Scott won by a unanimous decision. He won by 60–54 on all three scirecards. Scott then fought on the undercard of Andre Ward vs. Chad Dawson on September 8, 2012 at the Oracle Arena, Oakland, California. It was against Tongan heavyweight contender Bowie Tupou. Scott won the fight by an 8-round TKO. On January 10, 2013 it was announced that Scott would face off against unbeaten heavyweight contender Vyacheslav Glazkov. The fight took place on February 23, 2013 and ended in a draw, the first blemish on Scott's record. On July 20, 2013 Scott fought Derek Chisora for the vacant WBO International Heavyweight title. The fight took place at the Wembley Arena in London, England and Scott suffered his first defeat, a sixth round knockout. Having been floored, he waited until the referee counted to nine to get up, but was adjudged to have been counted out in the act of rising. On January 24, 2014 Scott beat Grover Young by a stoppage in the second round, before getting knocked out in the first round by Deontay Wilder on March 15, 2014. Scott then fought crafty southpaw veteran and somewhat of a gatekeeper, Tony Thompson, on October 30, 2015. The fight was scheduled for ten rounds and Scott went on to win the fight via unanimous decision despite being knocked down in the ninth round. On November 12, 2016 he fought Cuban boxer Luis Ortiz in Monaco. Despite claiming to have a perfect camp, the bout was largely uneventful and disappointing. Scott was on the backfoot for most of the fight and seemed completely unwilling to engage with Ortiz. British commentator Adam Smith lamented the bout as "the worst I have seen in many years". Matchroom promoter Eddie Hearn was also visibly disappointed after the bout and claimed that "Scott didn`t do us any favours tonight". The official scorecards were 120–105, 120–106, and 119–106 all in favor of Ortiz.
