Mwanakatwe is a business executive and banker, with a professional career spanning over twenty years. She has been a banking chief executive in her native Zambia, Ghana, and Uganda and a senior executive at the United Bank for Africa in Nigeria.
Following education both in Zambia and abroad, she took up employment at Barclays Bank of Zambia. She rose to the position of managing director. She was the first Zambian and first female chief executive at Barclays Bank of Zambia. She was also the first woman CEO in all of Barclays Bank's African subsidiaries at the time. In 2004, she was appointed managing director and CEO at Barclays Bank of Ghana, serving in that capacity until 2009. In 2009, she left Barclays Bank and joined the UBA as managing director and chief executive at United Bank for Africa Uganda Limited. During the same timeframe, she served as the regional business director for southern Africa for UBA. In 2011, she left UBA Uganda and transferred to the headquarters of UBA in Lagos, Nigeria as the director for business development in Anglophone Africa.
Politics
On 2 February 2015, Mwanakatwe was nominated Member of Parliament and appointed Minister of Commerce by Zambia President Edgar Lungu. She was elected as Member of Parliament for Lusaka Central Constituency, which was previously held by Mr Guy Scott's. 4 February 2018, in a cabinet reshuffle, she was appointed Minister of Finance. With the Zambian economy struggling a number of key projects have stalled, Mwanakatwe's extensive experience in banking provides her with relatively reasonable experience to add value to the Ministry of Finance, restore investor confidence and to create new economic partners. In her role as Minister of Finance, Mwanakatwe has tasked her department to work effectively in order to ensure that the ministry satisfies the expectations of the electorate. In a meeting held on 20 February 2018, the minister requested that her team formulate a plan to offset domestic arrears in a systemic manner. Additionally, in this meeting she directed officials to formulate a sustainable plan to pay salaries to public service workers on time and commended the team for its commitment to improving domestic resource mobilisation. She was relieved of her duties as Finance Minister by President Lungu on 14 July 2019.
Other responsibilities
Margaret Mwanakatwe is married to Mupanga Mwanakatwe, who serves as the managing director of , the state-owned telecommunications company.