Maria Theresa was born in Florence, Italy, the eldest child of Grand DukePeter Leopold of Tuscany and his wife Maria Luisa of Spain. As such, she was also the eldest grandchild of Charles III of Spain. Like all the eldest daughters of the children of her paternal grandparents, she was named after her grandmother, the Habsburg ruler Maria Theresa. Maria Theresa and her siblings were given a somewhat different upbringing than was usual for royal children at the time: they were actually raised by their parents rather than a retinue of servants, were largely kept apart from any ceremonial court life and were taught to live simply and modestly.
Marriage
On 8 September 1787, Maria Theresa was married to Prince Anthony of Saxony by proxy in Florence; the couple later married in person in Dresden on 18 October 1787. Anthony had previously been married to Maria Carolina of Savoy, who died of smallpox in 1782. Mozart's opera Don Giovanni was originally intended to be performed in honor of Maria Theresa and Anthony Clement for their visit to Prague on 14 October 1787, as they traveled between Dresden and Vienna, and librettos were printed with dedication to them. The premiere could not be arranged in time, however, so the opera The Marriage of Figaro was substituted on the express orders of Maria Theresa's uncle, Holy Roman Emperor Joseph II. The choice of The Marriage of Figaro was considered improper for a new bride by many observers, and the couple left the opera theater early without seeing the entire work performed. Mozart complained bitterly of the intrigues surrounding this incident in a letter to his friend Gottfried von Jacquin that was written in stages between 15 October and 25 October 1787. She was also present in Prague in September 1791 for the premiere of Mozart's opera La clemenza di Tito, which was written as part of the celebrations there in honor of the coronation of her father as King of Bohemia. Maria Theresa was described as a simple and homely character devoted to a private family life, and she was reportedly relieved to marry a spouse who was, at the time of their marriage, not expected to succeed to a throne. Her four children all died as infants. However, at the death of her cousin and sister-in-law, Princess Carolina of Parma, she and her other sister-in-law, Amalie of Zweibrücken-Birkenfeld, shared the responsibility of raising the former's children, something they are said to have done very strictly.
Later life
Maria Theresa assisted her father, by then Holy Roman Emperor, to arrange the meeting between Austria, Prussia and the French émigrées in Saxony, which resulted in the Declaration of Pillnitz25 August 1791. In 1806, she and her family fled Saxony for Prague during the war against Napoleon I. They were able to return in 1813. She was able to enjoy the title queen of Saxony for only a few months after the death of her brother-in-law Frederick Augustus I in May 1827. The latter's alliance with Napoleon led to significant losses of territory for Saxony at the conclusion of the Napoleonic Wars. Maria Theresa died at Leipzig in 1827.
Issue
Maria Theresa and Anthony were parents to four children, all of whom were born and died in Dresden; none survived to the age of two:
Maria Ludovika Auguste Fredericka Therese Franziska Johanna Aloysia Nepomucena Ignatia Anna Josepha Xaveria Franziska de Paula Barbara.
Frederick Augustus.
Maria Johanna Ludovica Anna Amalia Nepomucena Aloysia Ignatia Xaveria Josepha Franziska de Chantal Eva Apollonia Magdalena Crescentia Vincentia.
