Maribel Parra de Mestre was born on 24 August 1965 to Guillermo Parra and Ledia Perozo at the Central Hospital in Maracaibo in Zulia. She completed primary and pre-school education at the Simon Rodriguez School and secondary education at the José Ramón Yépez Institute in Zulia. After graduating from high school in June 1982 she chose to enter the Military Academy of the Bolivarian Navy rather than the University of Zulia. She graduated on 5 July 1986, 11th in her class of several hundred. Parra de Mestre was commissioned as an alférez de navío with a specialism in electronics. She completed the marine training course in 1988 and afterwards graduated from the National Experimental University of the Armed Forces with a master's degree and was promoted to the rank of frigate lieutenant. After promotion to the rank of lieutenant she served as an aide to the First Lady of Venezuela. Parra de Mestre was subsequently promoted to frigate captain and travelled to the United States for one year to study at the Western Hemisphere Institute for Security Cooperation. After her return to Venezuela she became deputy commander of the navy academy cadet battalion and, after promotion to the rank of captain, became director of the Navy's supply and commissariat department. She later became head of logistics for the VargasInfantry Division. Parra de Mestre is married to Amilcar Mestre and has two daughters Amibel and Maribel. She was a supporter of former president Hugo Chávez.
Admiral
Parra de Mestre was promoted to the rank of rear admiral on 5 July 2011, becoming the first woman from Zulia to attain this rank. On 4 July 2014 she became the first Venezuelan woman to achieve the rank of vice admiral when President Nicolás Maduro promoted her to this rank. The next day she became the first woman to lead the combined civil and military parade held annually on the anniversary of the signing of the Venezuelan Declaration of Independence.
On 29 January 2017 Parra de Mestre was appointed executive vice president of PDVSA, the Venezuelan state-owned oil company by President Maduro. The move was part of a whole-scale replacement of the company's board of directors an attempt to reduce corruption and strengthen the management of the company as part of Maduro's "Plan Guayana Socialista". The move was seen as part of a takeover of the oil sector in the country by the military.