Reneau began her professional mixed martial arts career in 2010. After winning several professional fights she attempted to try out for. However, she was allegedly told by UFC brass that she was too old to be a contestant on the show, but to keep pressing on and to win a couple of more fights. On the heels of her submission victory over Maureen Riordan in July 2014 at Resurrection Fighting Alliance 16, she was signed by the UFC.
Ultimate Fighting Championship
Reneau faced Alexis Dufresne on January 3, 2015 at UFC 182. Reneau won the fight via unanimous decision. At the post fight press conference, Dana White made a point to mention the TUF snub and publicly praised her performance. Reneau faced Jéssica Andrade on February 22, 2015 at UFC Fight Night 61. Reneau won the fight via first round submission, earning a Performance of the Night bonus. Reneau faced Holly Holm on July 15, 2015 at UFC Fight Night 71. She lost the fight by unanimous decision. Reneau faced Ashlee Evans-Smith on February 21, 2016 at. She lost the fight by split decision. The judges' decision was controversial as 16 of the 17 media sources scoring the fight scored it for Reneau. She planned to appeal the decision with the Pennsylvania State Athletic Commission. However, the appeal was denied by the PSAC. Reneau faced Milana Dudieva on November 19, 2016 at UFC Fight Night 99 in Belfast, Northern Ireland. She won the bout by TKO in the third round. Reneau then faced Bethe Correia on March 11, 2017 at. The back-and-forth fight saw strong moments from both women, 2 of the 3 Judges gave the first two rounds to Correia and gave the third round to Reneau ultimately causing the fight to end in a majority draw. After the fight, Reneau disagreed with the result and said “I believe she won the first round; maybe she might’ve edged me out a little bit. I think I definitely won the second – and for sure I won the third round." Reneau was expected to face former UFC Women's Featherweight ChampionGermaine de Randamie on September 2, 2017 at, however, De Randamie pulled out of the fight on August 25 citing injury and was replaced by Talita Bernardo Reneau won the fight via TKO in the closing seconds of the third round. Reneau was scheduled to face former Invicta FC bantamweight champion Tonya Evinger at on February 18, 2018. However, on January 9, 2018, it was announced that Evinger was forced to pull out from the fight due to injury, resulting Reneau being pulled from the event and rescheduled to face Sara McMann on February 24, 2018 at UFC on Fox 28. After being dominated the first round, she rallied back in the second round by knocking McMann down and then submitted her. Reneau faced Cat Zingano at UFC Fight Night 133 on July 14, 2018. She lost the fight by unanimous decision. Reneau faced Yana Kunitskaya on March 9, 2019 at UFC Fight Night 146. She lost the fight by unanimous decision. Reneau was scheduled to face Irene Aldana on September 21, 2019 at UFC on ESPN+ 17. However, Reneau pulled out of the bout on September 11 for undisclosed reasons. She was replaced by Vanessa Melo. Reneau was scheduled to face Ketlen Vieira on May 9, 2020 at UFC 250. However, on April 9, Dana White, the president of UFC announced that this event was postponed to a future date. Instead Reneau faced Raquel Pennington on June 20, 2020 at. She lost the fight via unanimous decision.
