Chmura was drafted in the sixth round of the 1992 NFL draft, and selected to the Pro Bowl in 1995, 1997, and 1998. He played for the Packers from 1992 to 1999, whom he assisted to Super Bowl XXXI and Super Bowl XXXII. He scored the final points of Super Bowl XXXI with a 2-point conversion catch, and he finished Super Bowl XXXII with 4 catches for 43 yards and a touchdown. In 1997, Chmura chose not to meet with United States PresidentBill Clinton at the White House following the Packers Super Bowl XXXI win. While many claimed that this was because Chmura was a staunch Republican, the meeting fell on the same day as the annual Mike Utley golf tournament. The tournament is something that Chmura had played in every year since 1992 to honor former Detroit Lion player Mike Utley who had been paralyzed on the field.
Release
Chmura suffered a career-ending herniation of his C5 and C6 discs in his cervical spine. Chmura was released by the Packers in 2000. After his release, he attempted a comeback, with the Washington Redskins and the New Orleans Saints showing interest, but suffered a relapse of the injury while working out in his weight room and retired. In 8 seasons with the Packers, Chmura finished his career in third place all-time in franchise history among tight ends with 188 receptions 2,253 yards, and 17 touchdowns in 89 games. In 2010, he was inducted into the Green Bay Packers Hall of Fame.
Criminal charges
On April 8, 2000 Chmura was accused of sexually assaulting the 17-year-old babysitter of his children. Chmura was tried but found not guilty of all charges. Two days after being acquitted of child enticement and third-degree sexual assault, Chmura acknowledged that his behavior at a post-prom party "wasn't something a married man should do."
Post-football career
In 2004, Chmura began hosting a Sunday morning Packers pregame show on ESPN 540 in Milwaukee and is still presently hosting the show each week. As of 2019, he also hosts The Show with Gabe Neitzel during weekday mornings on WAUK. The Show tackles a variety of Wisconsin sports topics. From 2005 to 2009, Chmura worked as a research assistant for the Boyle Law Group. He was also an assistant football coach at Waukesha West High School, where his son, Dylan, played tight end, and son Dyson also played at Waukesha West. Dylan also played for Michigan State University. In 2017, Chmura was hired as the offensive coordinator of Greenfield High School under head coach Keith Ringelberg. In 2010, Mark Chmura was inducted into the Packer Hall of Fame. Chmura divorced in 2010 from his former wife Lynda Stickler. In 2011, Chmura married Angela Goff. Currently, the Chmuras and their children reside in Wisconsin. Along with his spouse Angela, Chmura owns a chain of auto collision repair businesses.