Patton grew up in Riverside, Missouri and, after graduating high school, he moved to New York City to pursue an acting career. Within a few years he landed the role of Joe Qualley in the 1982 Broadway production of Come Back to the Five and Dime, Jimmy Dean, Jimmy Dean. Patton reprised the role in the 1982 film of the same name. His character in the play and film was a pre transition teen Transgender Woman, Patton was not allowed to do an interview with the LGBT-interest magazine, The Advocate. Patton identified this as an early indicator of the homophobia in Hollywood at that time. In 1985, Patton landed the lead role in the horror film ' portraying Jesse Walsh, a teen whose body becomes possessed by Freddy Krueger. Critics and audiences noted the gay subtext of the film, something screenwriter David Chaskin initially attributed to Patton's portrayal of Jesse. However, in the 2010 documentary ' Chaskin acknowledged that he, himself, was responsible for the film's deliberate gay subtext. Patton had a guest appearance on the television series Hotel and had scenes alongside George Clooney and Maud Adams. He also starred in a television pilot with Chuck Connors entitled Kelsey's Son, which was never picked up. Other roles include General Hospital as Greg Collier, Misplaced with John Cameron Mitchell, Anna to the Infinite Power with Dina Merrill and Martha Byrne and Have You Tried Talking to Patty with Heather Langenkamp. Patton says he gave up on his acting career following being cast in a planned CBS series in which he would have played a gay character. "They began to ask me if I would be comfortable playing a gay character and telling people I was straight if they began to question my sexuality?...All I could think about was how everyone I knew was dying from AIDS and we were having this bullshit conversation. My heart just broke and that was the line for me. I knew I would never be able to do what they were asking, so I walked away from Hollywood and decided to move on to a place where it was totally acceptable to be gay." In December 2015, it was announced that Patton was cast in the independent paranormal horror film, Family Possessions, which is written and directed by Tommy Faircloth of Horse Creek Productions. Mark will play the role of Tyson, a male Regina George who torments a new girl in town with his best friend Tristen. Filming took place in March 2016 in Greenville, North Carolina. Family Possessions had its World Premiere in mid October 2016 and won many awards at film festivals around the globe. This film marks the first horror movie Mark has acted in since . In February 2018, "Family Possessions" was released on North American by 4Digital Media/Sony Pictures. It was also released in South Korea and Taiwan.
Personal life
Patton is openly gay. On his 40th birthday, he was diagnosed with HIV along with pneumonia, thrush and tuberculosis. His medications interacted badly and he was hospitalized. Upon recovering, he moved to Mexico, where he met and later married Hector Morales Mondragon. The couple owns and operates an art store in Puerto Vallarta. Patton appears in the A Nightmare on Elm Street documentary , directed by Dan Farrands. Following his appearance in the documentary Patton began touring horror conventions where he is lauded as mainstream cinema's first male "scream queen". He donates most of his appearance fees to HIV treatment groups and charities benefiting LGBT youth such as The Trevor Project.