Lowton was born in Chesterfield, Derbyshire. He joined Sheffield United aged fifteen after a spell with Leeds United and progressed through Sheffield United's youth set up to reserve level, converting from a full-back to a central defensive role in the process. After spending a spell on loan at Sheffield FC in 2008, in January 2009, Lowton went out on loan to Sheffield United's Hungarian sister club Ferencváros, along with fellow reserve playerSam Wedgbury, to get first-team experience. He made his debut in the Hungarian League Cup the next month, making twenty appearances for the club. Back in the Championship, Lowton found himself on the fringes of the first team and duly made his Blades debut in a 1–1 draw with Cardiff City at the end of March 2010, coming on as a late substitute, before making his full debut for the club in the final match of the season. The following season, Lowton started Sheffield United's opening day fixture, away to Cardiff City, but was issued with a straight red card. Despite this setback, he returned to the first-team picture and was rewarded with a new contract at the end of September. Lowton continued a run of substitute appearances and rewarded United's faith by scoring his first senior goal in mid-October, netting in a 3–3 home draw with Burnley. Lowton played regularly for the remainder of the season, scoring four goals in all, but couldn't prevent the club from slipping to relegation. With the Blades in League One at the time, Lowton remained a key player and was rewarded with an extended contract in August 2011, making 55 appearances in total for the Blades during the following season and scoring six goals.
Aston Villa
Lowton completed a move to Aston Villa in July 2012 for an undisclosed fee, believed to be £3 million, becoming Paul Lambert's second signing as Villa manager, and made his debut on 18 August 2012, in the Premier League against West Ham United. On 15 September, Lowton scored his first league goal for Villa in a 2–0 home win against Swansea City. On 19 July 2013, Lowton signed a new four-year deal to keep him at Aston Villa until the summer of 2017.
Burnley
On 22 June 2015, Burnley secured the signing of Lowton on a three-year deal for an undisclosed fee believed to be around £1 million plus add-ons. Lowton made his debut for Burnley on 20 October, as an 84th-minute substitute against Nottingham Forest; his first start came against Charlton Athletic on 19 December. His first and only goal of the season was Burnley's fourth in a 5–0 rout of Milton Keynes Dons on 12 January 2016. Lowton would make 27 appearances in his maiden season at Burnley, all in the League, as Burnley won the Championship title and earned promotion to the Premier League.
