McDonough

• Adam McDonough, American mixed martial artist
• Al McDonough, retired Canadian professional ice hockey player
• Alexa McDonough, Canadian politician
• Ann Patrice McDonough, retired American competitive figure skater
• Blair McDonough, Australian actor
• Bob McDonogh, American racecar driver
• Brian McDonough, American physician and writer
• Bridget McDonough, American businesswoman
• David McDonough, New York Assemblyman
• Darron McDonough, English footballer
• Denis McDonough, Deputy National Security Advisor for Strategic Communications to President Barack Obama
• Frank McDonough, British historian of 20th-century Germany
• Gabe McDonough, Canadian record producer who is the vice president music director at Leo Burnett USA.
• George MacDonogh, British Army general officer.
• Giles MacDonogh, British writer, historian and translator.
• Gordon L. McDonough, U.S. Representative from California
• Guy McDonough, Australian rock musician
• Harry Macdonough, Canadian singer and recording executive
• Hubie McDonough, retired American professional ice hockey centre
• Jack McDonough, Australian rules footballer who played with South Melbourne and Fitzroy in the VFL during the early 1900s
• Jenny McDonough, field hockey forward who plays for Ireland
• John McDonogh, United States entrepreneur and philanthropist, founder and namesake of McDonoghville now McDonogh, Louisiana, absorbed by Gretna, Louisiana in 1913.
• John Joseph McDonough, politician and a businessman from Georgia, US
• John McDonough, president of the Chicago Blackhawks ice hockey team
• John E. McDonough, professor of public health at the Harvard School of Public Health.
• John J. McDonough, mayor of St. Paul, Minnesota
• John P. McDonough, American politician from Maryland
• John T. McDonough, Irish born-American lawyer and politician
• Kiki McDonough, British jewellery designer
• Martin McDonogh, Irish politician
• Mary Elizabeth McDonough, American actress
• Matthew McDonough, drummer for American heavy metal band Mudvayne
• Megon McDonough, American folk/cabaret singer/songwriter
• Neal McDonough, American actor
• Pat McDonough, US Maryland politician
• Patrick MacDonogh, 20th-century Irish poet
• Patrick "Pat" McDonough, American track cyclist
• Paul McDonough, professional American football player who played end for four seasons for the Pittsburgh Pirates and the Cleveland Rams
• Pete McDonough, San Francisco bail bondsman
• Roger I. McDonough, American judge, served on the Utah Supreme Court from 1938 to 1966
• Roy McDonough, English football player and manager who holds the record for red cards in the English professional game
• Ryan McDonough, several people
• Sean McDonough, American television sportscaster
• Suzanne Clarke McDonough, American journalist, documentary filmmaker
• Thomas Macdonough, 19th-century American naval officer
• Will McDonough, American sportswriter for the Boston Globe
• William McDonough, award-winning American architect and author notable for his work in the field of sustainable development
• William Joseph McDonough, former Federal Reserve Bank of New York chairman

• Jefferson "Seaplane" McDonough, pilot in the film and its, portrayed by Nick Jonas.