Mehdi Frashëri was born in 1872 in the village of Frashër in the Përmetkaza, to Ragip bey kaymakam of Metsovo. He studied in Konica and Monastir and graduated from the Mekteb-i Mülkiye in Istanbul in 1897. While in Constantinople, in 1901, he was charged with establishing a small press in a local house cellar for printing Albanian nationalistic materials together with a small group of Albanians.
Frashëri was against Benito Mussolini and disliked his policy of invading Albania. Frasheri took it upon himself to broadcast scathing attacks against the invasion as well as addressing a remonstrance to Mussolini. Following the departure of the government of Tirana, he urged young men with revolvers to distribute themselves to preserve order. When the invading troops were at the gates he sought asylum in the Turkish Legation, continuing to refuse to sign a declaration in support of the Italians. His personal courage impressed even the German minister, who successfully appealed to Rome to allow Frashëri to return home. Despite Italian guarantees, Frashëri was soon arrested and interned in Italy. Frashëri participated as "Honorary Chairman" of the Conference of Pezë, where Albanian anti-fascist factors gathered in 1942, a fact that would be suppressed by the communist regime later. Frashëri, who had sympathy for the Germans partly because he had studied in Austria, worked with German minister, in the hopes of establishing closer relations and to gain some protection for the Albanians from the Italians.
German occupation
After the capitulation of Italy, Nazi Germany took control of the Balkans. The Germans were apprised of his significance and began to search for him immediately after the invasion. Frasheri was found and agreed, on 16 September, to return to Tirana for talks with Hermann Neubacher, Major and. After the end of the meeting, it was agreed that Albania would have its own sovereignty under Nazi Germany, similar to the Independent State of Croatia. Frashëri agreed to serve as regent as well as head the council. The leadership of the council was originally designed to rotate, but Lef Nosi declined for health reasons, and Anton Harapi argued that as a Catholic monk, he could accept no position in which he would be forced to sanction the death penalty.
When the Partisans declared victory in Albania, the Germans evacuated, taking Mehdi Frashëri with them. Frashëri moved to Vienna and eventually settled in Rome, where he lived until his death.