After auditing scriptwriting classes and doing research for the head writer of Mary Hartman, Mary Hartman, Markoe was hired as writer for the 1977 revival of Laugh-In, joining a team that included Robin Williams. In 1978, she was part of the cast of Mary Tyler Moore's first attempt at a variety show, the eponymous Mary, along with future boyfriend David Letterman. In 1980, Markoe was the head writer for The David Letterman Show, a short-lived live NBC morning show whose writing team was recognized with a Daytime Emmy Award. Markoe shared in three Primetime Emmy Awards for Outstanding Writing for a Variety Series for her work on Late Night with David Letterman, for which she was the original head writer. She engineered most of the original concepts and architecture for the ground-breaking late-night talk show and created the segment "Stupid Pet Tricks", as well as "Stupid Human Tricks" and "Viewer Mail." Many of the ideas behind the remote segments outside the studio came from Markoe, who also won a Writer's Guild award for her writing/performing work on HBO's Not Necessarily the News. She has also written for television shows such as Newhart, Sex and the City, and Moonlighting. She appeared on-camera as a lifestyle reporter at KCOP-TV in Los Angeles, then for Michael Moore's NBC show TV Nation, and worked on other magazine shows such as Lifetime Magazine. In the early 1990s she wrote and directed a number of HBO and Cinemax comedy specials. She appeared in two episodes of Space Ghost Coast to Coast from 1997–1998 as the unwilling subject of the eponymous late night talk show host's affections. In 2005, Markoe was a regular panelist on Animal Planet's Who Gets the Dog? She has had a number of columns and written for many periodicals including Rolling Stone, Time, New York Woman, New Woman, USNews and World Report, US, People, Esquire, The Huffington Post, Glamour, The New York Times, The Los Angeles Times, LA Weekly, Real Simple, etc. She appears in episode 2 of Friends as irritable museum curator Marsha and can be seen in the movie EDtv as a panelist, as well as in the cast of The Aristocrats. In 2020, she was awarded the prestigious Paddy Chayefsky Laurel Award for Television Writing Achievement by the Writer's Guild of America as a result of her writing that led to the popularization of the Letterman Show.
Personal life
She and David Letterman were involved romantically from 1978–1988, after which Markoe moved to California to pursue a writing career. She wrote about the relationship several years later in essays in the book Cool, Calm, and Contentious, giving him the pseudonym "Bobby". Markoe lives in Malibu with musician Andy Prieboy and four dogs.
