Mesozoa were once thought to be evolutionary intermediate forms between Protozoans and Metazoans, but now they are thought to be degenerate or simplified metazoa. Their ciliated larva are similar to the miracidium of trematodes, and their internal multiplication is similar to what happens in the sporocysts of trematodes. Mesozoan DNA has a lowGC-content. This amount is similar to ciliates, but ciliates tend to be binucleate. Others relate mesozoa to a group including annelids, planarians, and nemerteans.
Groupings
The two main mesozoan groups are the Dicyemida and the Orthonectida. Other groups sometimes included in the Mesozoa are the Placozoa and the Monoblastozoa. Monoblastozoans consist of a single description written in the 19th century of a species that has not been seen since. As such, many workers doubt that they are a real group. As described, the animal had only a single layer of tissue.
Rhombozoan mesozoans
Rhombozoa, or dicyemid mesozoans, are found in the nephrid tracts of squid and octopuses. They range from a few millimeters long with twenty to thirty cells that include anterior attachment cells and a long central reproductive cell called an axial cell. This axial cell may develop asexually into vermiformjuveniles or it may produce eggs and sperm that self-fertilize to produce a ciliated infusiform larva. There are three genera: Dicyema, Pseudicyema and Dicyemennea. Molecular evidence suggests that this phylum are derived from the ''Lophotrochozoa.
Orthonectid mesozoans
Orthonectida are found in the body spaces of various marine invertebrates including tissue spaces, gonads, genitorespiratory bursae. This pathogen causes host castration of different species. The best known of Orthonectida is the parasite of brittle stars. The multinucleate syncytial stage lives within tissues and spaces of the gonad but can spread into arms. It causes the destruction of starfish ovary and eggs to cause castration. The stages of the plasmodium develop into more plasmodia by simple fragmentation; at some point, they decide to go sexual. The syncytia are dioecious, but young syncytia can fuse to produce both male and female. The males are ciliated and smaller than the females. The females and the males leave the starfish and mate in the sea. Tailed sperm enters the female and fertilizes the numerous oocytes. Each oocyst produces a small ciliated larva which makes its way to another star. The genome of one of these species – Intoshia linei – has been sequenced. The Orthonectids may be degenerate annelid worms.