Born in Pittsburg, Texas, Jefferson was the only child of Millard and Guthrie Jefferson, a Methodist minister, and a school teacher. Her parents divorced before 1976 and lived in Roxbury after their divorce. Jefferson was raised in Carthage, Texas, in the Wesley-Calvinist tradition. At a young age, "Millie" followed the town doctor around on his horse drawn buggy while he made housecalls, this would later inspire her to become a doctor. She earned her bachelor's degree in three years from Texas College. Since she was considered too young to attend medical school, she went to Tufts University where she received her master's degree in biology. She then went on to Harvard Medical School and graduated in 1951, becoming the first black woman to do so. Jefferson married in 1963 to Shane Cunningham, whom she met on a skiing trip, a real estate manager. As of 1976, the couple lived in Back Bay and had no children.
Career
Jefferson achieved board certification in surgery in 1972. After graduating from medical school, she did a surgical internship at Boston City Hospital, becoming the first woman to do so. She was also the first female doctor at the former Boston University Medical Center. By 1984, Jefferson was a general surgeonat the Center and a professor of surgery at the Boston University School of Medicine. She would later become the first woman to become a member of the Boston Surgical Society. Though she did not perform an abortion herself, Jefferson did provide post-operative care after an abortion.
Pro-life work
One root of Jefferson's opposition to abortion was her dedication to the Hippocratic oath, which morally bound her to the preservation of life. Her interest in abortion issues was triggered when she was asked to sign a petition opposing a resolution proposed by the American Medical Association supporting liberalization of abortion-related laws. It was around 1970 when Jefferson became one of the founders of Massachusetts Citizens for Life. She later helped found the National Right to Life Committee. In 1971, she became a member of the NRLC board of directors. She became the vice president of the National Right to Life Committee in 1973 and then was elected as chairman of the board the following year. Mildred then was elected as president of NRLC, serving three terms from 1975 to 1978. Jefferson concurrently wrote a column, "Lifelines", in the National Right to Life News publication. In 1975, Jefferson was the first witness for the prosecution in the manslaughter case levied against Kenneth Edelin for his performance of a legal abortion. It was in 1980 that Jefferson helped the National Right to Life Committee start a political action committee because she believed it was important to lobby and support pro-life candidates for office. While a Republican, she helped Democrat Ellen McCormack run for the Democratic Party presidential nomination in 1976. Apart from NRLC, Jefferson served on boards of directors of more than 30 pro-life organizations. Jefferson is also noted for changing Ronald Reagan's stance on abortion from pro-choice to pro-life. He wrote to her in a letter, "You have made it irrefutably clear that an abortion is the taking of a human life, I am grateful to you."
Political activities and positions
Jefferson supported the one issue, pro-life 1975–6 campaign of Ellen McCormack for president and appeared in television advertisements for McCormack. Jefferson was a self-described "Lincoln Republican" and served on the 1980 Massachusetts Reagan for President Campaign. Jefferson had first met Reagan in 1973 while he was governor of California. She also unsuccessfully sought the Republican nomination for the 1982, 1990, and 1994 U.S. Senate elections. Jefferson opposed the Equal Rights Amendment on the basis that it is unnecessary as the Constitution has no in-built inequity. She for years called for a constitutional amendment to reverse the 1973 Supreme Court decision in Roe v. Wade, rejecting the notion that abortion is a private matter between a woman and her physician. Jefferson has also expressed opposition to welfare and busing, and support for the death penalty.
Death
Jefferson died in her Cambridge home on October 15, 2010, at the age of 83 years. She was divorced and had no children. She was buried in her hometown of Carthage, Texas.