Regev was born in Kiryat Gat in 1965 to Sephardi Jewish immigrants. She went to Rogozin Highschool in Kiryat Gat. Her father, Felix, was from Morocco and her mother, Mercedes, was from Spain. In 1983, she joined the Gadna, where she became a platoon commander, serving in the position until 1986. She earned a Bachelor's Degree in Informal Education and an MBA.
In November 2008, Regev joined the Likud party, saying that she had been a supporter of the party's platform for many years. She won twenty-seventh place on the party's list for the 2009 elections, just high enough to enter the Knesset as Likud won 27 seats. At the 2015 elections Regev was re-elected, after being placed fifth on Likud's national list. She was subsequently appointed by prime minister Netanyahu to Minister of Culture and Sport in the new government. Revital Madar, a Tunisian-Israeli writer for Haaretz, stated that Regev had faced discrimination due to her Moroccan origins, and her forthright behaviour is perceived as being stereotypically Mizrahi.
Minister of culture
In September 2015, four months in office, Regev announced a list of criteria that will cause the withdrawal of state funding the following year. The list included the deformation of state symbols and a call for boycotting Israel. In July 2016, Regev announced that she would not participate in the 2016 Summer Olympics opening ceremonies, because they take place on Shabbat. In her position as Minister of Culture, Regev frequently equates artistic Freedom of Expression with the power of the government to withdraw its funding, using the term "Freedom of Funding". Regev also argued that state-funded artists or organisations must show "loyalty" to the Israeli state. She has called this a "Loyalty in Culture" initiative, and has proposed legislation making "support for a cultural institution dependent on its loyalty to the state of Israel". She has said the group Breaking the Silence "hurts Israel's image" and accused a gallery that had hosted a talk by the group of "holding political activities". At the closing ceremony of the 2017 Maccabiah Games on July 18, 2017, Regev passed the Maccabiah torch to a number of Maccabiah athletes.
Minister of Transportation and National infrastructure
In May 2020, Regev was offered the portfolio of Minister of Transportation for the first half of the 35th government of Israel and the portfolio of foreign minister during the second half of the incoming government's term. She was sworn in to this position on 17 May 2020.
Views
Immigration from Africa
In May 2012, at a demonstration against illegal immigrants in Tel Aviv, Regev said that "Sudanese infiltrators are a cancer in the nation's body". She later said that the quote was misrepresented, and, while justifying the comparison, apologized for seeming to compare human beings to cancer.
LGBT rights
Regev met with LGBT community members of her party, and said, that "not only the left can support and embrace the gay community".
Personal life
She is married to Dror Regev, an engineer at Israel Aerospace Industries and has three children. Her husband is from a left-wing background and holds some views opposing her own.