All of the route is located in Hancock and Pearl River counties. MS 607 starts at a T-intersection with US 90, and travels westward. The route goes through a forest as a divided highway. Nearly later, MS 607 intersects MS 604 as it turns northwest. After passing by two electrical substations, it crosses a road that leads to the Mississippi welcome center and INFINITY Science Center, a NASA visitor center. The route then intersects I-10 at a diamond interchange, and state maintenance ends just north of it. United States government maintenance begins, and the road soon turns north. About later, MS 607 travels through an access gate and enters Stennis Space Center. Past the access gate, the road crosses over a canal and intersects road that leads to an old alignment of MS 43. MS 607 later shifts northwest until it meets H Road. It then travels north through thick forests for more than, until it reaches Gravel Pit Road, where it begins traveling northwest. South of Turtleskin Creek, MS 607 reaches to an access gate. State maintenance begins at the intersection of Texas Flat Road and the old alignment of US 11. The route continues traveling northwest through the forest, entering Pearl River County and intersecting Asa McQueen Road. Small houses soon appear, and the route meets US 11 and I-59 at a diamond interchange. The road continues on into Picayune as US 11. In 2013, Mississippi Department of Transportation calculated as many as 11,000 vehicles traveling west of MS 604, and as few as 3,400 vehicles traveling south of Texas Flat Road. All of the road is maintained by MDOT and the United States Government. MS 607 is not included as a part of the National Highway System, a network of highways identified as being most important for the economy, mobility and defense of the nation. MS 607 is part of two scenic routes and memorial designations. Hospitality Highway, which is designated from I-10 to US 90. NASA Scenic Byway to Space, starting at the intersection of MS 607 and MS 604 to the south gate of the center, then from the north gate to Texas Flat Road.
History
The road that became part of MS 607 was part of US 90 and US 11 since 1928, and all of it became paved by 1934. In 1936, a new road was built from US 90 to south of Slidell, and US 90 was soon rerouted to it. The road between US 11 and US 90 became MS 11-90. By 1939, US 90 was moved to another new road, bypassing the old one. The MS 11-90 designation was temporarily removed in 1942, and was restored the next year. In 1948, MS 11-90's designation was removed, and the road became part of MS 43. Between 1958 and 1960, I-59 and I-10 were proposed. Meanwhile, the United States Army Corps of Engineers began buying land in Hancock County for the Mississippi Test Operations in 1962, which later became Stennis Space Center. In 1967, MS 43's alignment was moved east of NASA's test site, and the old alignment became MS 607. Only north and south of the test area were state maintained. Also in the same year, MS 607's interchange with I-10 was completed. In 1971, MS 607 south of the Stennis Space Center became a divided highway.
