In 2015, Missouri Department of Transportation calculated as many as 2,454 vehicles traveling on Route 164 west of I-55, and as few as 482 vehicles traveling east of Route H. This is expressed in terms of annual average daily traffic, a measure of traffic volume for any average day of the year. The route is located in rural Dunklin and Pemiscot counties. Route 164 starts at US 412 and Route F on the southern city limit of Cardwell. The route travels north into the city as Main Street, and intersects the southern terminus of Route V at Pool Street. Route 164 travels eastward and leaves Cardwell past County Road 613. The road crosses over Kennemore Slough and intersects US 412 for the second time. Route 164 continues eastward through farmland, and intersects Route 108 on the western side of Arbyrd. The routes are briefly concurrent, and Route 108 continues northward at Frisco Street. Route 164 travels along the city limit for Arbyrd and leaves the city at CRD 625. The road crosses over another river near Hollywood. The Hornersville Memorial Airport is located past Route K, west of the Hornersville. Route 164 intersects Route YY on the northern edge of the city and begins travelling north soon after. The road turns northeastward and parallels Little River until it reaches the unincorporated area of Cotton Plant. Inside the area, the route intersects Routes N and Y, resumes travelling eastward, and crosses over the Little River. West of CRD 709, Route 164 crosses over two unnamed streams. The road intersects Route TT, southwest of the village of Rives. It soon meets the terminus of Route PP, which leads to the center of the village, less than one mile later. At the Dunklin-Pemiscot county line, Route 164 intersects Route NN. West of Denton, the road intersects Routes C and F. Route 164 shifts southwards near the Steele Municipal Airport. At Administration Drive, the road enters the city limits of Steele. The route turns northeast at First Street and turns southeast at Route Z. Travelling on Main Street, the route enters the center of the city and crosses the River Subdivision railroad. The route becomes concurrent with US 61 at Walnut Street. Travelling away from downtown Steele, the road crosses over a creek and leaves city limits at Cooter Road. Route 164 and US 61 travels slightly northward at the diamond interchange with I-55. US 61 travels concurrently with the interstate, thus ending the concurrency with Route 164. The route shifts back southward at Outer Road. At Acorn Corner, the road intersects the northern terminus of Route H. Travelling across farmland, it meets Route D at a T-intersection. The route travels southwards to Cottonwood Point, where it intersects Route DD. Route 164 then travels southeastwards to its eastern terminus at CRD 553. The road continues as Ferry Landing Road, which leads to a boat ramp.
History
Around 1933, Route Y was designated along a gravel road from Cardwell to Caruth, through the community of Hollywood. About one year later, Route J was designated from Routes C and N near the Dunklin–Pemiscot county line to US 61 in Steele, and it was removed and designated as a part of Route N in 1937. The entirety of Route Y was paved by January 1946, at a cost of $38,233, and Route N was extended to Route Y by 1953, costing $133,138. The section of Route N from Route NN to US 61 was also paved during that time, and completely paved by 1955. In 1956, Route 164 was designated, replacing a majority of Routes N and Y. The route extended from Route 25 in Arbyrd to Route H east of Steele. Five years later, Route W was designated from the eastern terminus of Route 164 to Route D north of Cottonwood Point. Route 164 replaced Route W and was extended to Cottonwood Point by 1965. By 1972, Route 25 was rerouted between Cardwell and Arbyrd, and its old alignment through Cardwell was added to Route 164. An interchange at I-55 opened in November 1973, as part of a $13.5 million project. By 1983, Route 25 from the Arkansas–Missouri state line to Kennett was replaced by US 412.
