Mixed lineage kinase domain like pseudokinase


Mixed lineage kinase domain like pseudokinase is a protein that in humans is encoded by the MLKL gene.

Function

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3, which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis.

Influence in diseases

High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. . Some reports have linked it to unusual variants of multiple sclerosis