He was born into the Mirghani family in Mecca which was one of the most noble families that have descended from the Islamic prophetMuhammad. He is the son of Muhammad Abu Bakr who is the son of AbdAllah al-Mahjoub who is the son of Ibrahim who is a descendant of the Prophet Muhammad. The lineage of Muhammad Othman al-Mirghani was verified by Murtada al-Zubeidi and this was further verified by al-Jabarti in his book Taareekh al-Jabarti / al-Jabarti's History part two. Muhammad Othman al-Mirghani was born in Ta'if and died in Mecca and was buried there in AlMa'alla. His sons followed in his footsteps after his death, the most famous of whom were Muhammad al-Hassan al-Mirghani, Gaafar as-Sadig al-Mirghani, Abdullahi al-Mahjoub al-Mirghani, Hashim al-Mirghani and Sirr al-Khatim al-Mirghani.
Travels
Al-Khatim's religious journey began in Mecca from whence he travelled to Tarim in Yemen and then to Somalia by sea and to Massawa on the Red Sea coast where he travelled inland into the Ethiopian hinterland before returning to Mecca. On this trip tens of thousands of people embraced Islam including entire clans and tribes. His second trip started from the Egyptian countryside south of Cairo and he was accompanied by his teacher Ahmad ibn Idris who parted ways with him in AlZeyniyyah. AlKhatim traversed the Nubian lands of the Mahas and the Sakot and went to Kordofan and reached the lands of the Fur people and the Borno tribe. He then travelled to Sennar on the banks of the Blue Nile and then to Shendi via Gezira and via the Butana to the Taka Mountain region near Kassala from which he entered into Ethiopia and visited many regions before returning to Mecca.
Movementism
Muhammad Othman AlMirghani AlKhatim's methodology for calling people to Islam, "movementism", was characterized by travelling and being constantly on the move. This was due to the influence of Ahmad ibn Idris whose teachings and contribution coincided with a general, early Islamic renaissance during the Ottoman Caliphate. The customary, long-used methodology for an Islamicsheikh or Imam was to remain in his abode and for people to travel from afar to seek his audience. AlKhatim's "movementism" was the exact opposite of the customary methodology that had been prevalently used by Islamic sheikhs and Imams in his time. "Movementism" was similarly taken up by another of Ahmad ibn Idris's disciples, Senussi, who travelled to the Maghreb and founded what would eventually become the monarchy of Libya. However, AlKhatim travelled to regions and peoples where Islam was unknown and, if there was any knowledge of Islam, it was through the East African Slave Trade which caused many of these peoples to be hostile toward Islam. Examples of such regions are the Ethiopian Highlands and Eritrea and the southern region of the Blue Nile State and the Nuba Mountains, all of which have difficult terrains and complex tribal systems. AlKhatim, at only 25 yearsof age, managed to overcome personal physical risk, the harsh geography and the tribal complexities of these lands to call its people to Islam and to set up mosques and Islamic centres of learning which created a link between these lands and the Islamic World. Among his achievements was the establishment of the first teaching centre for the education of women in Sudan. His literary contribution to Islam spanned a wide range of topics from the explanation of the Quran, through the listing of the Hadith, Fiqh and behaviour, Muhammedan Biography, Madeeh or description of the Muhammedan traits to specific writings on many aspects of the Islamic religion. These are estimated to have reached over 112 many of which are yet to be disclosed.