Childers, affectionately called "Molly", was born into a reputable Bostonian family that lived at 8 Beacon Street, Beacon Hill, Boston, Massachusetts. Physically disabled from the age of three following a skating accident, Childers was educated at home and was not mobile for the first 12 years of her life. Eventually she was able to move enough to ride horses, but she was never capable of walking without crutches. Her father, Dr Osgood, was a student of Dr Louis Pasteur and spent time with him in France and Switzerland. It was this research with Pasteur that enabled him to bring the first rabies antitoxin back to Boston, and in turn the United States. The Osgood's ancestry was directly linked to John Quincy Adams and Anne Hutchinson, and Molly was very proud and outspoken about this connection. Molly's mother Margaret Cushing Osgood encouraged her to read and to pursue a life in academia, as her disability would hinder other careers. The Osgood family home on Beacon Street was next door to the Boston Athenæum. Molly spent years of her childhood inside this library, reading for hours every day; several members of the Osgood family were among the first proprietors of the institution.
Marriage
In late 1903, Molly was seated next to Erskine Childers at a dinner given by her aunt on Beacon Hill. Erskine was in Boston on a ceremonial trip with Lord Denbigh and the Honourable Artillery Company. By January 1904, after some weeks of courtship, the two were married at Trinity Church in Boston. One Boston newspaper described their wedding as the most "distinguished gathering" of the season.
In 2006, historian Michael T. Foy published a book "Michael Collins's Intelligence War: The Struggle Between The British and the IRA 1919–1921" in which he suggested that Molly Childers might have been a spy for the British during the Irish War of Independence. Foy speculated that she volunteered for British intelligence before the couple moved to Ireland in 1918. The claim was described by reviewers in Irish newspapers as "dramatic", "sensational" and "a bottle of smoke". The author discovered in British archives a series of intelligence reports which appeared to indicate that a woman with high-level access to Sinn Féin had been passing intelligence to the British forces. However, the name of the agent had been obscured by blue pencil in the British files stored in the UKNational Archives at Kew. The author noted circumstantial evidence which, in his opinion, suggested that Molly Childers might have been the spy, including the assertion that Childers had not shared her husband's enthusiasm for Irish independence, and the spy's use of American phraseology. He proposed that Molly Childers had "the qualities to carry off such a dangerous role" and that she "consistently displayed intelligence, courage, decisiveness and single-minded determination", but acknowledged that there was no conclusive evidence. However, Foy went beyond scholarly speculation when he claimed that Childers was the only person who could fit the profile of the spy. Nessa Childers, the daughter of Molly's son President Erskine Hamilton Childers, dismissed the evidence as "circumstantial", saying in a television interview that "it just doesn't fit with her character". She questioned the evidence that the spy was female, and noted that "Up until the day she died she had photographs of Liam Mellows, Liam Brady and Rory O'Connor on her bedside and she revered them. It doesn't follow that such a person could have put those people's lives at risk." Historian Peter Hart, who has consistently challenged republican historiography, said that Foy's theory "does seem to fit the facts as presented", but noted that "all the other facts we know about thoroughly republican Molly suggest that it simply cannot have been true, and there are other good reasons to be cautious". Hart noted that the inaccuracy of some of the intelligence suggested a source trying to tell British "hardliners just what they wanted to hear".