The conical Great Mound at Mound Cemetery is part of an Ohio Hopewell culture mound complex known as the Marietta Earthworks. Archaeologists estimate that it was built between 100 BC and 500 AD. Early European American settlers gave the structures Latin names. The complex includes the Sacra Via, three walled enclosures, the Quadranaou, Capitolium and at least two other additional platform mounds, and the Conus burial mound and its accompanying ditch and embankment. The complex was surveyed and drawn in 1838 by Samuel R. Curtis. This survey was incorrectly attributed to Charles Whittlesey by E. G. Squier and E.H.Davis in their Ancient Monuments of the Mississippi Valley, published by the Smithsonian Institution in 1848. At the time the complex "included a large square enclosure surrounding four flat-topped pyramidal mounds, another smaller square, and a circular enclosure with a large burial mound at its center." The Conus mound was listed on the National Register of Historic Places on February 23, 1973 as the Mound Cemetery Mound, site listing number 73001549. In 1990 archaeologists from the Cleveland Museum of Natural History excavated a section of the Capitolium mound and determined that the mound was definitely constructed by peoples of the Hopewell Culture.
The city of Marietta was developed in 1788 by migrant pioneers from Massachusetts, soon after the American Revolutionary War and organization of the Northwest Territory. The cemetery has the highest number of burials of American Revolutionary War officers in the country. The original pioneers, city founders from the Ohio Company of Associates, preserved the Great Mound from destruction by establishing the city cemetery around it. Many of the founders were officers of the Revolutionary War who had received federal land grants for military services. Among high-ranking officers buried at the cemetery are generals Rufus Putnam and Benjamin Tupper, who were founders of the Ohio Company of Associates; as well as Commodore Abraham Whipple and Colonel William Stacy. In 1825, General Lafayette of France, who fought with the Americans during the Revolution, visited Marietta. He said of the city's veterans: "I knew them well. I saw them fighting the battles of their country... They were the bravest of the brave. Better men never lived." The Washington County Historical Society compiled the a list of Revolutionary soldiers buried in Mound Cemetery, notable persons in that list shown below:
Col. Robert Taylor, first burial in the cemetery
Gen. Rufus Putnam
Griffin Greene, Sr., Quartermaster
Commodore Abraham Whipple
Col. Ebenezer Sproat
Col. William Stacy, Sr.
Gen. Benjamin Tupper
Maj. Anselm Tupper
Capt. Nathaniel Saltonstall
Samuel Hildreth, Sr.
The books of Samuel Prescott Hildreth, buried here, provide insight into the early history of Marietta and the Northwest Territory, and the lives of the soldiers and early pioneer settlers. Major General James Mitchell Varnum was originally buried in the Mound Cemetery. His remains were later moved to Oak Grove Cemetery in Marietta.