The two springs of the Mußbach rise a few hundred metres apart on the northeastern slope of the Hoher Stoppelkopf in the forest district of Wachenheim an der Weinstrasse. They converge after about. The stream, which usually carries very little water, enters the Silbertal in the forest district of Deidesheim. After it reaches the Neustadt suburb of Gimmeldingen in the Benjental valley. Here, it is joined by an unnamed right tributary. The tributary is only long, but carries much more water. Its origin is the Loosenbrunnen springs on the north flank of the 533-metre-high Weinbiet on the eastern edge of the Palatinate Forest. Between 1952 and 1988, water from the spring was pumped up and used as drinking water in the local bar of Weinbiethaus. The combined stream feeds a small reservoir serving tourism in the Gimmeldingen Valley and then reaches the vines landscape flanking the German Wine Route. Here, it flows through the Neustadt suburbs of Gimmeldingen and Mußbach. The confluence with the Rehbach, the northern tributary of the Speyerbach, is about southeast of this residential area.
In the Middle Ages, the water of the stream was used to drive twelve mills. Their sites are now connected by the Mühlenwanderweg. Among these are, in downstream order:
The Upper Mill in Deidesheim, so named because it was the highest of the mills on the Mußbach.
The building that is now Forsthaus Benjental was once a weapon forge, which used a water wheel to drive the iron hammer.
The Lower Mill was built in 1718 in the extreme northwest of Gimmeldingen. It was razed in a major fire in 1886.
The Platsche Mill was built in 1821 and decommissioned in 1900. Only a millstone remains.
The Talmühle was the best preserved and was converted into a restaurant.
As early as the Frankish times, a mill existed on the boundary of the former village of Lobloch, south of St Nicholas' Church in Gimmeldingen. Historians believe that the mill once formed the nucleus of the village.
The Wiedemann Mill at the border between Gimmeldingen and Mußbach remained in operation until the early 20th century and was then turned into a winery. The former mill wheel was last seen in the 1960s.