It was incorporated into the Ottoman Empire in 1517 with the rest of Palestine, and by the 1596 tax records it was located it nahiya of Gaza, part of Gaza Sanjak, with a population of 77 household, an estimated 424 persons, all Muslims. The villagers paid a fixed tax-rate of 25% on agricultural products, including wheat, barley, summer crops, fruit trees, goats and beehives, in addition to occasional revenues; a total of 10,350 akçe. All of the revenue went to a Waqf. In May 1863 Victor Guérin described it as a hamlet, still inhabited by a few families, and was designated to him by the name of Deir al Mokhalles, which Guérin translated as the Convent of the Saviour. He noted that the name probably derived from a former convent, which formerly existed at the place. An Ottoman village list of about 1870 showed that Meghallis had 27 houses and a population of 71, though the population count included men, only. In 1882, the PEF's Survey of Western Palestine described Mughullis as: "A village of moderate size, approached by an ancient road, and principally consisting of stone houses."
Mughallis became depopulated on July 9–10, 1948. On 16 July, Giv‘ati HQ informed General Staff\Operations that "our forces have entered the villages of Qazaza, Kheima, Jilya, ‘Idnibba and Mughallis, expelled the inhabitants, blown up and torched a number of houses. The area is at the moment clear of Arabs." The IDF were instructed to prevent infiltration to Summeil, Barqusya, Bi‘lin, Masmiya al Saghira, al Tina, Kheima, Idnibba, Jilya, Qazaza, and Mughallis. The orders specifically were to "destroy" any "armed force" encountered and to "expel.....unarmed villagers". During the following days, patrols expelled refugees near Tel as Safi, al Tina, and Mughallis, apparently killing three of those initially detained. In mid August 1948, a Giv‘ati patrol re-visited Idnibba, Mughallis, Jilya, Qazaza and Sajd, killing "a handful of Arabs" in a number of clashes. In 1955 Gefen was founded on village land, north of the village site. In 1992 the village site was described: "The site and surrounding area are fenced in. The debris from the houses have been levelled, and one can still see building components. Remnants of a house on the east side are ringed by stone markers that formerly identified the boundaries of a home garden. Numerous trees, including olive and carob trees, grow on all sides and cactuses are found on the northern and southern edges."
