After working in marketing and business development at Time Magazine, Jupiter Communications, and SportsIllustrated.com, Louie learned producing by producing NYU Tisch graduate thesis films, though she did not attend the school. Louie has premiered seven feature films at the Sundance Film Festival: Jennifer Fox's The Tale starring Laura Dern, Isabelle Nélisse, Ellen Burstyn, Jason Ritter, Elizabeth Debicki, and Common; Christina Choe's Nancy starring Andrea Riseborough, J Smith Cameron, Steve Buscemi, Ann Dowd, and John Leguizamo, Hannah Fidell's "The Long Dumb Road" starring Tony Revolori and Jason Mantzoukas; So Yong Kim's Lovesong starring Riley Keough and Jenna Malone; Martha Stephens & Aaron Katz's Land Ho! starring Paul Eenhoorn ; Marshall Lewy's California Solo starring Robert Carlyle ; and Tze Chun's Children of Invention starring Cindy Cheung. Her films have also premiered or screened at the Toronto International Film Festival, Venice Critics Week, SXSW, Tribeca Film Festival, Los Angeles Film Festival, Locarno Film Festival, London Film Festival, and Berlin Film Festival. Her first feature was Andrew Bujalski's critically acclaimed Mutual Appreciation, which she co-produced. Louie also produced or executive produced Aaron Katz's Gemini starring Lola Kirke, Zoë Kravitz and John Cho, Hannah Fidell's The Long Dumb Road starring Tony Revolori and Jason Mantzoukas, Sarah Adina Smith's Buster's Mal Heart starring Rami Malek, Natalia Garagiola's Temporada de Caza , Lauren Wolkstein & Christopher Radcliff's The Strange Ones, Karyn Kusama's The Invitation, Jamie Babbit's Addicted to Fresno, Patricia Benoit's Stones in the Sun starring Edwidge Danticat, Doug Karr's Art Machine, Ishai Setton's The Kitchen, Olivia Silver's Arcadia starring John Hawkes, and Tze Chun's Cold Comes the Night starring Alice Eve, Logan Marshall-Green, and Bryan Cranston. Louie previously served as the president of Gamechanger Films, a financing company that invested in women-directed narrative features. Louie also worked in economic development at the Hawaii Film Office, where she authored the state's refundable production tax credit and oversaw the renovation of the state-owned film studio. She was listed as one of Ted Hope's "21 Brave Thinkers of Truly Free Film" for the distribution strategy of Children of Invention, profiled in Indiewire's "Futures" column and in Crain's New York Business, and named one of Indiewire's "100 Filmmakers to Follow on Twitter." She serves on the Board of Directors of Film Independent, and as an advisor to the Sundance Institute, SXSW, IFP, and A3 Asian American Artists Foundation. Louie became a member of the Academy of Motion Picture Arts and Sciences in 2016.