NASDAQ Biotechnology Index

Criteria

• The security U.S. listing must be exclusively on the NASDAQ National Market.
• The issuer of the security must be classified according to the Industry Classification Benchmark as either Biotechnology or Pharmaceuticals.
• The security may not be issued by an issuer currently in bankruptcy proceedings.
• The security must have a market capitalization of at least $200 million.
• The security must have an average daily trading volume of at least 100,000 shares.
• The issuer of the security may not have entered into a definitive agreement or other arrangement which would likely result in the security no longer being Index.
• The issuer of the security may not have annual financial statements with an audit opinion that is currently withdrawn.
• The issuer of the security must have "seasoned" on NASDAQ or another recognized market for at least 6 months; in the case of spin-offs, the operating history of the spin-off will be considered.

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