In 2011 Nishino auditioned for Nogizaka46 and was selected as one of the 36 first generation members. She was chosen as one of the members performing on their debut single "Guruguru Curtain", released on February 22, 2012. On November 8, 2012, Nishino made her model debut walking the runway at GirlsAward 2012 Autumn/Winter with former Nogizaka46 bandmate Mai Shiraishi. She was selected as the choreographic center for the first time for Nogizaka46's 8th single "Kizuitara Kataomoi", which was released on April 2, 2014. Her first solo song, "Hitoriyogari" was included on Nogizaka46's debut albumTōmei na Iro, which was released on January 7, 2015. Nishino's first photo book, titled Fudangi, was published on February 18, 2015. It sold 36,000 copies in a week and ranked 1st on the Oricon weekly sales chart in the photobook category. She was the second member from Nogizaka46 to release a photo book, after Shiraishi. Nishino returned to the center position for the group's 11th single, "Inochi wa Utsukushii", which was released on March 18, 2015. The single also included her second solo song, titled "Gomenne Zutto..." as a B-side. She appeared in the fashion magazinenon-no as an exclusive model starting with the June 2015 issue. In July 2015 she played the lead role in the Nogizaka46 TV softball drama Hatsumori Bemars. On August 30, 2015, Nishino and Shiraishi were selected as Nogizaka46's first double center for their thirteenth single "Ima, Hanashitai Dareka ga Iru". On March 7, 2016, Nishino was announced as the co-host of the Fuji TV variety show Lion no Goo Touch. Her 2nd photo book, Kaze o Kigaete, was published on September 29, 2016. The included photos were taken in Malta and Italy over 5 days. Kaze o Kigaete ranked first on the Oricon book ranking in the photobook category for two consecutive weeks. On 22 September 2017, the film adaptation of the naginata manga Asahinagu was released, with Nishino playing the starring role of Asahi Tōjima. On September 20, 2018, Nishino announced her graduation from Nogizaka46 on the group's official blog. Her first post-Nogizaka46 acting role was as Yōko Matsuda in the 2019 TV Tokyo series Bet on This Girl! A supporting role in the NTV series It's Your Turn followed later that year.
