She was educated in the United States, attending Inglewood High School in California, before moving on to Los Angeles Southwest College. She made her Olympic debut at the 2000 Sydney Olympics and was just one of four competitors selected for the national Olympic team that year. Her next global appearances came at the 2001 World Championships in Athletics and she entered both the 100 metres and 200 metres competitions. Although she was eliminated in the heats of the latter event, she managed to reach the semi-finals of the 100 m and placed sixth in her heat. Mayers gained a place at University of Southern California and began competing for the USC Trojans women's track team. She was cleared to race in May 2002 after initial eligibility issues and ran in the 100 m and 200 m at that year's NCAA Outdoor Women's Track and Field Championship. Her Trojan's teammate Angela Williams won in the 100 m and Mayers finished one hundredth of a second behind her for second place. She had a personal record run of 22.80 seconds in the 200 m qualifiers, the third fastest ever time for a USC athlete, and then went on to secure the 200 m NCAA title in the final. Later that year she ran a 100 m best of 11.09 seconds at the Mt. SAC Relays. She represented her country at the 2002 Commonwealth Games and reached the finals of both the short sprints. She was eighth in the 100 m but was fourth over 200 m, missing the medals by a margin of 0.15 seconds.
Olympic flag bearer and doping ban
At the 2003 IAAF World Indoor Championships she ran in the 60 metres and just missed out on a spot in the final, finishing third in her semi-final. She equalled her personal best of 11.09 seconds at the Mt. SAC Relays, but did not get past the heats in her race at the 2003 World Championships in the outdoor season. She reached the 60 m semi-finals at the 2004 IAAF World Indoor Championships and again ran over 100 m at the major outdoor championship – her second Olympic performance at the 2004 Athens Games came to an abrupt end after she suffered a hamstring injury after reaching the quarter-finals stage. She was the Olympic national flag bearer at the Games opening ceremony and was chosen at the St. Vincent Sports Personality of the Year for her achievements later that year. She returned to St. Vincent in early 2005 and while there gave talks at local schools, promoting hard work and encouraging children to avoid the dangers of illegal drugs. In June that year she tested positive for excess testosterone against her epitestosterone levels and the IAAF gave her a two-year ban from the sport, stretching from June 2005 to June 2007. Later reflecting on the ban she said: "I just didn't know what to do. I went about it all wrong. I should have sought some help...I accepted the ban and that's that." She made her competitive return at the Athens Grand Prix Tsiklitiria, where she was runner-up in the 100 m behind Brianna Glenn.
After a break from the sport, she returned a few years later to run at the 2010 Commonwealth Games in New Delhi. She reached the women's 100 m final and came away with the Commonwealth gold medal after a chaotic series of events: A dual false start by Laura Turner and Sally Pearson, saw just Turner eliminated and Mayers finished third for the bronze medal behind Pearson and Oludamola Osayomi. Pearson was then disqualified on appeal, meaning Mayers was elevated to the silver medal behind Osayomi. However, the placings changed yet again as the Nigerian winner was disqualified after failing a drugs test, leaving Mayers as the event winner. This made her the first woman to win at the Commonwealth Games for Saint Vincent and Grenadines, the country's only medallist at the Games, and only their second gold medallist ever after Frankie Lucas's middleweight title at the 1974 edition. She competed sparingly after her Commonwealth Games win. She ran at the 2011 Central American and Caribbean Championships, but did not start in the final. She was a non-starter at the 2011 World Championships in Athletics. Her fastest run in 2012 was 11.50 seconds for the 100 m and in 2013 she slowed further to 11.80 seconds. With the 2014 Commonwealth Games forthcoming, she raised awareness that she lacked the funds to return to defend her title. She received a grant from the Prime Minister in 2011 but criticised the lack of support from her sporting federation otherwise.
