List of highways numbered 280

Australia

• McIvor Highway

  Canada

• Manitoba Provincial Road 280
• New Brunswick Route 280

  Japan

• Japan National Route 280

  United States

• Interstate 280
• U.S. Route 280
• Arizona State Route 280
• Arkansas Highway 280
• * Arkansas Highway 280 Spur
• Florida State Road 280
• Georgia State Route 280
• Kentucky Route 280
• Maryland Route 280
• Minnesota State Highway 280
• Montana Secondary Highway 280
• New York State Route 280
• North Carolina Highway 280
• Pennsylvania Route 280
• South Carolina 280
• Tennessee State Route 280
• Texas State Highway 280
• * Texas State Highway Spur 280
• * Farm to Market Road 280
• Utah State Route 280