Nemika Sultan was born on 9 March 1888 in the Yıldız Palace. Her father was Şehzade Mehmed Selim, and her mother was Iryale Hanım, the daughter of Hassan Ali Marshan and Fatma Horecan Aredba. Her mother was the sister of Nazikeda Kadın, first wife of Sultan Mehmed VI. She was the second child and only daughter of her parents. She had an elder brother Şehzade Mehmed who died young. She was the granddaughter of Sultan Abdul Hamid II and Bedrifelek Kadın. In March 1898, she attended the wedding of her aunt Naime Sultan, daughter of Abdul Hamid II and Bidar Kadın, and Mehmed Kemaleddin Pasha, son of Gazi Osman Pasha. During the ceremonial occasion, she sat with her aunts Şadiye Sultan and Ayşe Sultan. Nemika lost her mother in 1904 when she was sixteen years old.
Marriage
Nemika Sultan married Ali Kenan Isin Bey on 22 June 1911 in the Yıldız Palace. The couple was given Göztepe Palace as their residence. She gave birth to the couple's first child, a daughter, Fatma Fethiye Hanımsultan on 13 November 1912. On 14 September 1915, she gave birth to her second child, a son, Sultanzade Ibrahim in the Göztepe Palace. On 1 March 1920, she gave birth to her third child, a son, Sultanzade Kazim in the Göztepe Palace. At the exile of imperial family in March 1924, Emine Nemika and her family settled in Paris, France, where she gave birth to her fourth and last child Emine Satia Hanım on 15 January 1927. In exile, one her sons worked in Saudi Arabia and Kuwait. Her grandson married a British origin woman in 1983, who later became a Muslim and took the name Azize. All of her children are deceased, some her grandchildren including Selma Sibai Osmanoğlu and Orhan Osmanoğlu are still alive today. One of her grandson died in 2009. She was widowed by the death of her husband in 1962.
Death
In 1952, with the revocation of law of princesses, she came back to Istanbul and settled in Bostancı district. According to her grandson, she wanted to return to her homeland before she died. Nemika Sultan died on 6 September 1969 at the age of eighty-one and was buried in the mausoleum of Şehzade Kemaleddin, located in Yahya Efendi Cemetery, Istanbul.