Neuroprotectin
Neuroprotectin D1 also known as Protectin D1 is a docosanoid derived from the polyunsaturated fatty acid docosahexaenoic acid, which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective bioactivity. Other neuroprotectins with similar activity include: PDX ; 20-hydroxy-PD1 ; and 10-epi-PD1. The activity of neuroprotectin-like metabolite, 17-epi-PD1, has not yet been reported.
Neuroprotectins A and B, which are bicyclohexapeptides, are to be distinguished structurally and mechanistically from the neuroprotectin D's.
