Longworth was born in Newark, New Jersey on January 16, 1783. He moved to Cincinnati, Ohio in 1804 and married Susanna Howell, three years his junior, daughter of Silas and Hannah Howell, on Christmas Eve, 1807. His Greek Revival villa, then on the eastern edge of Cincinnati, is now the Taft Museum of Art in Cincinnati. Nicholas pursued the study of law under Jacob Burnet, one of Cincinnati's first millionaires.
Winemaking
Believing Cincinnati to be an ideal location for grape cultivation, he established viticulture as a successful venture on the hills adjoining the city. He planted a vineyard of Catawba on the Mount Adams hillside and began making a sparkling wine from the grapes using the traditional method used in Champagne. From the 1830s through the 1850s, Longworth's still and sparkling Catawba were being distributed from California to Europe where it received numerous press accolades. In the 1850s, a journalist from The Illustrated London News noted that the still white Catawba compared favorably to the hock wines of the Rhine and the sparkling Catawba "transcends the Champagnes of France". The wines were also well received at home in the United States where Henry Wadsworth Longfellow published a poem dedicated to Nicholas Longworth titled Ode to Catawba Wine. The popularity of Longworth's wine encouraged a flurry of plantings along the Ohio River Valley and up north to Lake Erie and Finger Lakes region of New York. So successful was he that he has been called the Father of American Grape Culture. The growing tide of German immigrants coming down the Ohio Valley to Cincinnati liked his wine. Longworth had found a lucrative market: the new German immigrants wanted an affordable, drinkable table wine to continue with the traditions of their homeland, and he enjoyed a virtual monopoly. With his success in wine making, Longworth participated in charitable giving throughout Cincinnati, including a noteworthy donation to the land which the Cincinnati Observatory is built on. Besides being a pioneer and leading horticultural expert in his section, he was recognized as an authority in national horticultural matters. His writings, though individually short and now out of date, exercised a wide influence in his day.