Danti's political career started in 1990, aged 24, when he was elected in Pontassievemunicipal council. He later became deputy-mayor of Pontassieve, from 1995 to 1999. In 2002, he was also elected president of the Florentine Mountain Community, an office that he will keep until 2008. He has been a member of several local authorities' associations. From 2004 to February 2007 he was coordinator of The Daisy for the area of Florence, succeeding Matteo Renzi. Danti became a member of the regional council of Tuscany on July 24, 2007, with responsibility for agriculture and housing policies. He is re-elected in March 2010, within Florence electoral district. From 2010 to 2014 he was the president of the regional council's committee for education and culture. He was the first signatory of the regional law 70/09 “Interventions in support of the couples engaged in international adoption”. During the center-left coalition primary election of November–December 2012, he was the coordinator of Renzi's committees in Tuscany. He was a member of the National directorate of the Democratic Party and the spokesman of the regional secretaryship of the party.
Member of the European Parliament, 2014–present
In April 2014, Danti was among the candidates of the Democratic Party for the upcoming European elections, in the Central Italy district. With 80,100 votes, he came fifth of his list and was elected member of the European Parliament. Danti is a member of the Group of the Progressive Alliance of Socialists and Democrats in the European Parliament. From 2014 until 2019, he served as the S&D group's coordinator on the Committee on the Internal Market and Consumer Protection before joining the Committee on International Trade in 2019. He is also member of the Parliament's delegations for relations with Brazil and Mercosur. He was also a substitute member of the European Parliament's Committee of Inquiry into Emission Measurements in the Automotive Sector. Within the IMCO Committee, Danti served as rapporteur for the “market surveillance” Regulation, for the “Single Market programme” and rapporteur on two resolutions on the “collaborative economy” and on “professional services”. He was also shadow-rapporteur on the Network and Information Security directive and as rapporteur for the opinion on the “Cybersecurity Act”; shadow-rapporteur for the opinion on the European Fund for Strategic Investments ; rapporteur for the opinion on the possible extension of EU geographical indication protection to non-agricultural products; standing shadow rapporteur on the EU-Mercosur Association agreement. In addition to his committee assignments, Danti is a member of the European Parliament Intergroup on Integrity He has also been committed to the protection of the “Made in” productions and in favour of the TTIP resolution. In February 2020, Danti announced that he'll move to the group of Renew Europe in the European Parliament.