The street was laid out in 1891 and named for Prince Albrecht of Prussia, son of King Friedrich Wilhelm III, who had owned a large house called Prinz-Albrecht-Palaison the corner of this street and Wilhelmstraße. In 1905 an extension building of the Museum of Decorative Arts was erected adjacent to the Martin-Gropius-Bau on Prinz-Albrecht-Straße 8. From May 1933 this building served as the headquarters of the Gestapo created by the order of Hermann Göring, where many political prisoners were tortured and executed. In December 1934, it also housed the headquarters of the Concentration Camps Inspectorate, which oversaw all the concentration camps. It formed the nucleus of the complex of buildings including the neighbouring Hotel Prinz Albrecht on Prinz-Albrecht-Straße 9 and the Prinz-Albrecht-Palais itself, which was taken over by the Sicherheitsdienst under Reinhard Heydrich in 1934. In September 1939, it developed into a centre for the Reich Main Security Office which was created by Heinrich Himmler and placed under the command of Reinhard Heydrich for the whole of Germany and occupied Europe. Himmler himself operated out of the building from an office on the top floor, thus making #8 Prince Albrecht Street the default headquarters for the entire SS. The buildings, including the first building of the Ethnological Museum of Berlin, were destroyed by Allied bombing in early 1945 and demolished after the war. After World War II, in 1951, the authorities of East Berlin renamed Prinz-Albrecht-Straße to Niederkirchnerstraße in honour of Käthe Niederkirchner, a member of the communist resistance to the Nazis. The Berlin Wall ran along the southern side of the street from 1961 to 1989, one of the few preserved sections is located at the eastern end.
A building referred to as "SS Headquarters" appears in the 2008 motion picture Valkyrie, the complex shown appearing as a large concrete building in a plaza draped with swastika flags. The mini-series further depicts SS headquarters as a grand hotel in a courtyard plaza, with the interior shown as a large lobby with a grand staircase leading up to Heinrich Himmler's office. Both depictions in no way resemble the historic Prinz-Albrecht-Straße, although "Hitler's SS" did accurately depict the building as being located within a former hotel. Numerous historical novels and thrillers set in Nazi Germany have sections taking place in the Prinz-Albrecht-Straße headquarters.
