Night Shift Nurses, as was originally written for the game, takes place in an undisclosed area of Japan, mainly at the fictional St. Juliana Hospital. A majority of the game is portrayed on campus with minor visits to the character's residences and surrounding towns.
Plot
Yakin Byōto 1: Ryuji Hirasaka is an unemployed, middle-aged Japanese gynaecologist, single, independent, and living on his own. One evening, he receives an email from the fictional St. Juliana Hospital, a local institution, offering him a temporary job opportunity. He contently accepts, scheduling to meet with the president the following day. That afternoon, semi-formal and with a portfolio, Ryuji commutes to the hospital. After an acquaintance with Ren Nanase, a nurse who escorts him to the president, he is frightened to discover his potential employer is a woman he had brutally raped in the past, Narumi Jinguji. In spite of the excruciating atmosphere, however, Narumi explains her wish to develop a department in the hospital that caters to the sexual interests of patients; in need of his expertise to oversee the operation. Overwhelmed with lewd excitement, Ryuji agrees. Yakin Byōto 2: A young elite doctor Souichiro Kuwabara couldn't forget his feelings towards Ren Nanase, whom he had fallen in love with back in his training days. He's been switching occupations at different hospitals one after another, to go look for her, and finally he meets her again at the Sei-Katorea General Hospital. However, her attitude was remote and sadly enough his love couldn't be fulfilled. To make things worse and more complicated, he finds a stack of photographs depicting Ren being molested. Ren had been turned into a lewd woman by Hirasaka when she was still working at St. Julianna. He was very disappointed after what he had witnessed to the point where he ends up losing his mind and going insane-. Yakin Byōto 3: Yotsuya Jiro, an aspiring novelist was lying in front of a hospital. He was seriously injured, and when he though he was about to die, a pink haired nurse named Yuu Yagami, helped him. He was sent into an emergency ward, and he met a beautiful woman, Reika Mikage. She is a director of the hospital, and she asked him to become a test subject. Because he didn't have any relatives, he accepted it. Then, Yuu was supposed to take care of him. Since that day, his fate had changed a lot. Yakin Byōto Zero: This is the back story of how the genius doctor Ryuuji Hirasaka acquired his perverted pastime as a med school student. He and Narumi Jinguuji are rivals at the top of their class. One day, Narumi tells him that if he can seduce the woman she designates in the 2 weeks before graduation, she'll admit her defeat and do anything he tells her. The girls she suggests are just as beautiful and desirable as herself. Sensing his perverted perceptions transforming into a talent at her tantalizing suggestion, he readily agrees.
As a result of the unrestrained content of the series, Night Shift Nurses is usually regarded as one of, if not the most graphic hentai ever released. Several minutes of particularly unruly scenes were even banned from North American releases. Industry aggregator Mania.com gave the series an F, citing that although the animation is "clean" and "slick", the quantity of edits made for the American release yields it one that "I in no way recommend."
