Much of the area is rural, and the only city within the region with a population of over 100,000 is Santa Rosa. Despite their relatively smaller size to the major cities elsewhere in the state, many of the region's cities and towns have historical importance to the State and/or regional importance.
The Pacific Ocean coast stretches from San Francisco Bay to Humboldt Bay and on to the border of Oregon. The coastline is often inaccessible, and includes rocky cliffs and hills, streams and tide pools. The coastline from Centerville Beach near Ferndale to the mouth of the Klamath River is mostly beach accessible and there are many small towns and a few cities along Highway 101, the main route through the region. The sparsely populated interior territory further inland is characterized by rugged, often steep mountains, bisected by rivers and their typically narrow valleys and canyons, and dense redwood, Douglas fir, and oak forests. The climate can range from coast side lands drenched with fog in mild winters and summers to inland reaches baked by hot sunshine on long summer days, which, at higher elevations, can be blanketed with snow in winter. The southern portion of the North Coast is largely urbanized while the rest is mostly rural. The more remote northern areas are often referred to as being located "behind the Redwood Curtain." A segment of the coastline in Mendocino and Humboldt Counties is known as the Lost Coast, and is only accessible by a few back roads. Notable seaside beaches can be found at Marin Headlands and Point Reyes National Seashore in the south, with innumerable examples of remote or less used beaches north of the San Francisco Bay area. The grandeur of the redwoods can be experienced throughout the region, from the protected groves of Muir Woods National Monument and Armstrong Redwoods State Natural Reserve in the south to the massive forests of Humboldt Redwoods State Park along the Avenue of the Giants in the north. Redwoods are also found in many other State and local parks, most of which are located along Highway 101 throughout the far North Coast. Other larger redwood parks include Prairie Creek Redwoods State Park, Del Norte Coast Redwoods State Park, Jedediah Smith Redwoods State Park and Redwood National and State Parks. In total, the redwood parks of the North Coast contain the vast majority of all remaining old-growth redwoods.