Nuclear receptor coactivator 1
The nuclear receptor coactivator 1 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.
NCOA1 is also frequently called steroid receptor coactivator-1.Interactions
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix domain and has been shown to interact with:
- Androgen receptor,
- C-Fos,
- C-jun,
- CIITA,
- CREB-binding protein,
- Cyclin D1,
- DDX17,
- DDX5 and
- Estrogen receptor alpha,
- Glucocorticoid receptor,
- NFKB1,
- PCAF,
- PPARGC1A,
- Peroxisome proliferator-activated receptor alpha,
- SNW1,
- STAT3,
- STAT6,
- TRIP4, and
- Thyroid hormone receptor beta.
