O'Toole (surname)
- O'Toole family, a leading family in Gaelic Leinster
People
- Adam Dubh Ó Tuathail, heretic, executed 1327
- Annette O'Toole, American dancer and actress
- Anton O'Toole, Irish footballer
- Chauncey O'Toole, Canadian rugby player
- Donald L. O'Toole, American politician
- Edmund O'Toole, soldier won the Victoria Cross in the Anglo-Zulu war
- Erin O'Toole, Canadian politician
- Fintan O'Toole, columnist and drama critic for The Irish Times
- Gary O'Toole, Irish Olympic Swimmer
- James O'Toole
- James O'Toole , Irish-American gangster in Boston area
- Jason O'Toole , Irish author and senior editor of Hot Press magazine
- Jason O'Toole , vocalist for New York hardcore band Life's Blood
- Jed O'Toole, American musician
- Jennifer Cook O'Toole, American author
- Jim O'Toole. American baseball player
- Joe O'Toole, Irish politician
- John O'Toole, politician in Ontario, Canada
- John-Joe O'Toole, Irish footballer
- Kate O'Toole, radio presenter from Sydney, Australia
- Kathleen O'Toole, former police commissioner of Boston, Massachusetts
- Kevin J. O'Toole, American Republican Party politician
- Kevin O'Toole, Canadian bodybuilder and mixed martial artist
- Lawrence M. O'Toole, Interim Police Commissioner of Metropolitan Police Department, City of St. Louis
- Lorcán Ua Tuathail, Archbishop of Dublin and Saint
- Mark O'Toole , British bassist
- Matt O'Toole, TV actor
- Maureen O'Toole, American water polo player and coach
- Mick O'Toole, Irish racehorse trainer
- Mor Ui Thuathail, Queen of Leinster
- Muirchertach Ua Tuathail King of Ui Muirdeaigh, father-in-law of Diarmait Mac Murchada
- Paddy O'Toole, Irish politician
- Pat O'Toole, Canadian lacrosse player
- Peter O'Toole, Irish actor
- Randal O'Toole, American economist and public policy expert
- Tom O'Toole
Fictional characters
- Plenty O'Toole, in the 1971 James Bond film Diamonds Are Forever
- JD O'Toole, in Grand Theft Auto: Liberty City Stories