The newscast covers the most significant news and features in six regions in Mindanao; Davao Region, Northern Mindanao, Caraga, Soccsksargen, Bangsamoro Autonomous Region in Muslim Mindanao, and Zamboanga Peninsula, through the network's news teams from Southern Mindanao and news stringers across the island group. The newscast airs from Monday to Friday from 5:00 PM to 5:30 PM, preempting the first 30 minutes of Wowowin on GMA Davao, GMA Northern Mindanao and GMA General Santos with simulcast over TV-4 Dipolog, TV-3 Pagadian, TV-11 Iligan, TV-12 Bukidnon, TV-5 Ozamiz, TV-26 Butuan, TV-10 Surigao, TV-2 Tandag, TV-9 Zamboanga, TV-12 Kidapawan, TV-12 Cotabato, and TV-12 Jolo and over radio on a slightly-delayed basis via Super Radyo DXGM 1125 AM Davao. One Mindanao is also re-aired for national viewers under GMA News TV's primetime block "GMA Regional TV Strip" on a weekly basis. It airs every Thursday at 10:00 PM since May 21, 2020. The program also airs worldwide on GMA News TV International.
History
As Testigo (1999-2014)
Its main newscaster is Tek Ocampo, he started with Testigo on October 4, 1999 and made a name as a national reporter for GMA News when he left the show in 2002. After his stint with GMA Manila, he came back to Davao to anchor the program once more. To strengthen the regional network's commitment of bringing the latest, most credible and most comprehensive news from the region, in February 2013, the newscast started its international broadcast on GMA News TV International alongside other regional newscasts Balitang Amianan and Balitang Bisdak. Testigo ended its 15-year run on November 7, 2014.
On November 10, 2014, the newscast adopts the branding of its now-main newscast 24 Oras as 24 Oras Southern Mindanao, following their change of graphics and theme music of the network's flagship newscast of the same name. Since February 1, 2016, this program is the only GMA regional newscast to use the 24 Oras branding after two of its other regional newscasts reverted branding to its original names, Balitang Amianan and Balitang Bisdak.
As 24 Oras Davao (2016-2017)
On October 3, 2016, 24 Oras Southern Mindanao changed once again its branding simply as 24 Oras Davao. The rebranding coincided to the 17th anniversary of the regional network's news department alongside GMA Cebu's Balitang Bisdak, as well as expanding out the coverage of GMA Dagupan's Balitang Amianan. On January 2, 2017, the newscast updated its opening billboard, soundtrack and lower third graphics similar to 24 Oras, together with other newscasts Balitang Amianan and Balitang Bisdak. On April 17, 2017, senior correspondent Real Sorroche was promoted as anchor of the newscast, with the launch of his own segment Usapang Real.
As One Mindanao (2017-present)
With the end of 24 Oras Davao, GMA Regional TV launched a news program scoping the entire Mindanao island called One Mindanao. The newscast is also considered as the successor for other news programs produced by GMA for Mindanao, namely 24 Oras Northern Mindanao of GMA Northern Mindanao and Soccksargen Isyu Karon and Flash Bulletin of GMA General Santos. On July 29, 2019; the newscast unveiled a minor revision of its titlecard, changing its font color to green, reflecting it with its co-produced GMA Regional TV Weekend News, which was launched on July 27. One Mindanao was relaunched on August 19, 2019, adopting graphics and studio set from the national newscast. In addition, the program opens its doors for viewers to become its live studio audience every Friday, similar to its sister regional newscast Balitang Bisdak.