Orexin antagonist
An orexin receptor antagonist is a drug that inhibits the effect of orexin by acting as a receptor antagonist of the orexin receptor. Potential applications include treatment of sleep disorders such as insomnia.Examples
- Almorexant, development of the drug was abandoned in January 2011
- Lemborexant
- Nemorexant
- Filorexant
- SB-334,867, has been shown to produce sedative and anorectic effects in animals,
- SB-408,124
- SB-649,868, in development for potential use in sleep disorders
- Suvorexant, approved for use in sleep disorders under the brand name Belsomra
- TCS-OX2-29, OX2 selective
- RTIOX-276, OX1 selective
