Taylor was born in Chicago and moved at a young age to Denver, Colorado, where he grew up. He originally grew up playing the banjo, but his father wanted him to be a jazz musician. Upon hearing that the banjo was originally an African instrument turned almost exclusively into a white bluegrass instrument in part through the derogatory black-face minstrel shows of the 19th century, Taylor dropped the banjo and began to focus solely on the guitar and harmonica. He played music professionally both in Europe and the United States in a variety of blues-oriented bands, including Zephyr, until 1977, when he left the music industry for other pursuits, including becoming an antique dealer. Taylor returned to music in 1995, and as of 2015, has released fourteen blues albums. His music tends to focus on the hard realities of life, especially relating to the black community. Some common themes in his music are murder, racism, poverty and the need for redemption. To date, Taylor has twelve Blues Music Awards nominations while White African was named 'Best Artist Debut'. Down Beat magazine critics' Poll named Taylor's Truth is Not Fiction as Blues CD of the Year for 2002. Living Blues readers' poll awarded Taylor the "Best Blues Entertainer" title in 2004. Down Beat named Taylor's Double V as Blues CD of the Year for 2005. Down Beat named Definition of a Circle as Blues CD of the Year for 2007. They also then named Recapturing the Banjo as "Blues CD of the Year, 2008." His 2008 effort, Recapturing the Banjo, was an attempt to reconnect himself and the world with the true African origins of the banjo. "There may not be," claimed Down Beat in a review, "a better roots album released this year or decade than Recapturing the Banjo." Taylor was the support act on Gary Moore's 2007/8/9 European tours and played on his last album. In May 2009, Taylor won a Blues Music Award for his banjo playing. He held the first Trance Blues Festival in Boulder, Colorado, in November 2010. Taylor's 2015 release Hey Joe Opus Red Meat was editor's choice for album of the year in Blues Music Magazine and Premier Guitar Magazine. It was named "Album of the Year" by Blues411 and #2 by Twangville, and one of the top 30 albums of the year by The Blues magazine. Down Beat gave it 4 and half stars and listed it as one of their top 100 albums of the year.
In 2005, Purvis of Overtown featured a score by Otis Taylor
The song "Nasty Letter" from Taylor's 2003 album, Truth Is Not Fiction, was featured on the soundtrack for the 2007 filmShooter.
Michael Mann's 2009 film Public Enemies featured two of Taylor's songs, "Ten Million Slaves" and "Nasty Letter". The former was also featured in the film's trailer.
In 2003, Blue Star released the Otis Taylor Banjoblaster
Family
Taylor married Carol Ellen Bjork in 1985. They have two daughters, Cassie Taylor and Jae Taylor. Taylor's eldest daughter, Cassie, is featured on many of his releases. She also plays several instruments including bass and vocals.