He was born about 1180 the eldest son of Duke Berthold of Merania and his wife Agnes of Rochlitz. On the death of his father in 1204, he succeeded him as Duke of Merania, while the margravial titles in Istria and Carniola were inherited by his younger brotherHenry II. On 21 June 1208, Otto married Beatrice II, Countess of Burgundy of House Hohenstaufen, daughter of late Count Otto I of Burgundy. At the wedding ceremony in Bamberg, the Hohenstaufen king Philip of Swabia was murdered, whereafter Otto approached his Welf rival Otto IV. However, the position of the Andechs dynasty was significantly weakened. Otto's brother Henry II was accused of having been involved in Philip's assassination and his estates were seized by Duke Ludwig I of Bavaria. Otto assumed the rule in the County of Burgundy, which was contested by the local Counts of Auxonne and in the long-time struggle, Otto even had to give the Burgundian lands in pawn to Count Theobald IV of Champagne. In 1217 Otto had joined the Babenberg duke Leopold VI of Austria and his brother-in-law King Andrew II of Hungary in the Fifth Crusade. In 1222, a dispute arose with Gerard I de Rougemont, the Archbishop of Besançon over the building of a castle which violated a vow taken by his predecessor, Otto I of Burgundy. When Otto failed to raze the castle or give an explanation for his actions, the archiepiscopal court excommunicated him and placed his lands under interdict. He immediately turned to his brother Ekbert, Bishop of Bamberg for help in Bamberg. On 20 October 1223, Otto issued five charters consisting of lavish donations to religious communities. In 1228 he inherited the Marches of Istria and Carniola, which his brother Henry II had regained shortly before. On Beatrice's death in 1231, he ceased to be Count and was succeeded by his son as Otto III. On his own death in 1234, he was further succeeded by his son as Otto II, Duke of Merania.
Otto III of Merania,, succeeded his mother as Count of Burgundy in 1231, and his father as Duke of Merania as well as Margrave of Istria and Carniola in 1234. He married Elizabeth of Tyrol, daughter of Albert IV, Count of Tyrol. With his death, the House of Andechs became extinct in the male line.
Margaret of Merania, married firstly, Přemysl of Bohemia, a younger son of King Ottokar I of Bohemia, and married secondly, Frederick, Count of Truhendingen.
