Oxidative decarboxylation
Oxidative decarboxylation reactions are oxidation reactions in which a carboxylate group is removed, forming carbon dioxide. They often occur in biological systems: there are many examples in the citric acid cycle.
Compared to Simple decarboxylation which belongs to Lyase group, Oxidative decarboxylation belongs to Oxidoreductase group.In the citric acid cycle pyruvate dehydrogenase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase catalyze oxidative decarboxylation reactions. Each reaction reduces NAD+ to NADH and generates CO2.Other occurrences
The transformation of glyoxylate to formic acid is also an oxidative decarboxylation.
